Malignant melanomas of the conjunctiva.
Malignant melanomas of the conjunctiva.
复制标题
结膜恶性黑色素瘤。
DOI：
10.1016/0002-9394(76)90487-6
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发表时间：
1976
影响因子：
4.2
通讯作者：
W. Clark
中科院分区：
文献类型：
--
作者：
V. Bernardino;M. Naidoff;W. Clark
使用克拉克分类对 23 例结膜黑色素瘤进行的回顾性研究表明，皮肤中描述的三种最常见的黑色素瘤形式——恶性雀斑黑色素瘤（哈钦森雀斑伴黑色素瘤）、浅表扩散性黑色素瘤和结节性黑色素瘤——可以在结膜中识别。与皮肤一样，与浅表扩散性黑色素瘤相关的预后相比，恶性雀斑样黑色素瘤似乎与良好的预后相关。这两种形式的黑色素瘤都与上皮内阶段相关，并且之前被归为一种指定的癌性黑色素病。尽管将来会确定明确的临床分化，但它们可以通过组织学来区分。然而，一些处于上皮内阶段的黑色素瘤无法明确分类。将所有结膜癌性黑色素病与哈钦森黑色素雀斑联系起来不再合理。
A retrospective study of 23 conjunctival melanomas using the Clark classification revealed that the three most common forms of melanoma described in the skin--lentigo maligna melanoma (Hutchinson's freckle with melanoma), superficial spreading melanoma, and nodular melanoma--can be recognized in the conjunctiva. As in the skin, lentigo maligna melanoma appears to be associated with a good prognosis compared to the prognosis associated with superficial spreading melanoma. These two forms of melanoma are both associated with an intraepithelial stage and had previously been grouped under one designate, cancerous melanosis. They can be distinguished histologically although definite clinical differentiation will be determined in the future. Some melanomas with an intraepithelial stage, however, cannot be definitely classified. Relating all conjunctival cancerous melanoses to Hutchinson's melanotic freckle is no longer justified.