Structure-Function Relationship and Diagnostic Value of Macular Ganglion Cell Complex Measurement Using Fourier-Domain OCT in Glaucoma
Structure-Function Relationship and Diagnostic Value of Macular Ganglion Cell Complex Measurement Using Fourier-Domain OCT in Glaucoma
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DOI：
10.1167/iovs.09-5053
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发表时间：
2010-09-01
影响因子：
4.4
通讯作者：
Kim, Chan Yun
中科院分区：
文献类型：
--
作者：
Kim, Na Rae;Lee, Eun Suk;Kim, Chan Yun
目的.目的探讨黄斑神经节细胞复合体（GCC）厚度与视功能的关系，并评价GCC厚度对早期、中度和重度青光眼的诊断价值。受试者在一天内接受了可靠的标准自动视野检查和光学相干断层扫描成像（采用视神经乳头（ONH）模式和GCC模式）。将GCC厚度与平均差（MD）和视野指数（VFI）进行回归分析，评价结构与功能的关系。并与视网膜神经纤维层（RNFL）厚度进行比较。受试者工作特征曲线（AUC）下的面积用于确定疾病严重程度与RNFL和GCC参数的昏迷性变化之间的关系。本研究纳入了103名正常对照受试者和138名青光眼患者。与线性模型相比，二阶多项式模型更好地描述了GCC厚度与MD（P < 0.001）和GCC厚度与VFI（P < 0.001）之间的关系。GCC模式参数，全球损失量（GLV），检测早期青光眼的AUC最高。早期青光眼的平均GCC厚度的AUC高于平均RNFL;但差异无显著性（P = 0.330）。曲线函数最好地描述了VF敏感性和GCC厚度之间的关系。黄斑GCC厚度和RNFL厚度在检测早期、中度和重度青光眼方面显示出相似的诊断性能。（Invest Ophthalmol维斯科学。2010; 51：4646-4651）DOI：10.1167/iovs.09-5053
PURPOSE. To assess the relationship between visual function and macular ganglion cell complex (GCC) thickness measured by Fourier-domain optical coherence tomography (OCT) and to evaluate the diagnostic value of GCC thickness for detecting early, moderate, and severe glaucoma.METHODS. Participants underwent reliable standard automated perimetry testing and OCT imaging with optic nerve head (ONH) mode and GCC mode within a single day. The relationship between structure and function was evaluated by comparing GCC thickness with mean deviation (MD) and visual field index (VFI), by regression analysis. The results were compared with those obtained for retinal nerve fiber layer (RNFL) thickness. The area under the receiver operating characteristic curve (AUC) was used to determine the relationship between disease severity and glaucomatous changes in RNFL and GCC parameters.RESULTS. One hundred three normal control subjects and 138 patients with glaucoma were included in the present study. Compared with linear models, second-order polynomial models better described the relationships between GCC thickness and MD (P < 0.001), and between GCC thickness and VFI (P < 0.001). A GCC pattern parameter, global loss volume (GLV), had the highest AUC for detecting early glaucoma. The AUC of mean GCC thickness for early glaucoma was higher than that of mean RNFL; however, the difference was not significant (P = 0.330).CONCLUSIONS. A curvilinear function best described the relationship between VF sensitivity and GCC thickness. Macular GCC thickness and RNFL thickness showed similar diagnostic performance for detecting early, moderate, and severe glaucoma. (Invest Ophthalmol Vis Sci. 2010; 51: 4646-4651) DOI: 10.1167/iovs.09-5053