Plasma lipid profiling shows similar associations with prediabetes and type 2 diabetes.
Plasma lipid profiling shows similar associations with prediabetes and type 2 diabetes.
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DOI：
10.1371/journal.pone.0074341
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Shaw J
中科院分区：
文献类型：
--
作者：
Meikle PJ;Wong G;Barlow CK;Weir JM;Greeve MA;MacIntosh GL;Almasy L;Comuzzie AG;Mahaney MC;Kowalczyk A;Haviv I;Grantham N;Magliano DJ;Jowett JB;Zimmet P;Curran JE;Blangero J;Shaw J
脂代谢与糖尿病前期（空腹血糖受损和糖耐量受损）和2型糖尿病之间的关系尚不清楚。我们推测，血脂的脂质组学分析可能会提高这种关系的理解。我们对来自澳大利亚糖尿病、肥胖和生活方式研究（AusDiab）的117名2型糖尿病、64名前驱糖尿病和170名正常葡萄糖耐受参与者的空腹血浆进行了脂质组学分析，测量了259种脂质，包括鞘脂、磷脂、甘油酯和胆固醇酯，然后验证了来自圣安东尼奥家庭心脏研究（SAFHS）的1076名个体的研究结果。对2型糖尿病（135种血脂）和前驱糖尿病（134种血脂）的相关性进行Logistic回归分析，调整多个协变量后。除了与二酰甘油、三酰甘油和胆固醇酯的预期关联外，2型糖尿病和前驱糖尿病与神经酰胺及其前体二氢神经酰胺、沿着磷脂酰乙醇胺、磷脂酰甘油和磷脂酰肌醇正相关。醚连接磷脂烷基磷脂酰胆碱和烯基磷脂酰胆碱观察到显着的负相关性。AusDiab队列中的大多数显著相关性（90%）随后在SAFHS队列中得到验证。与2型糖尿病相关的血浆脂质体的畸变明显存在于2型糖尿病发作之前的糖尿病前期。与2型糖尿病相关的脂质类别和种类为许多现有的血脂异常范例提供了支持，并提出了新的研究途径。
The relationship between lipid metabolism with prediabetes (impaired fasting glucose and impaired glucose tolerance) and type 2 diabetes mellitus is poorly defined. We hypothesized that a lipidomic analysis of plasma lipids might improve the understanding of this relationship. We performed lipidomic analysis measuring 259 individual lipid species, including sphingolipids, phospholipids, glycerolipids and cholesterol esters, on fasting plasma from 117 type 2 diabetes, 64 prediabetes and 170 normal glucose tolerant participants in the Australian Diabetes, Obesity and Lifestyle Study (AusDiab) then validated our findings on 1076 individuals from the San Antonio Family Heart Study (SAFHS). Logistic regression analysis of identified associations with type 2 diabetes (135 lipids) and prediabetes (134 lipids), after adjusting for multiple covariates. In addition to the expected associations with diacylglycerol, triacylglycerol and cholesterol esters, type 2 diabetes and prediabetes were positively associated with ceramide, and its precursor dihydroceramide, along with phosphatidylethanolamine, phosphatidylglycerol and phosphatidylinositol. Significant negative associations were observed with the ether-linked phospholipids alkylphosphatidylcholine and alkenylphosphatidylcholine. Most of the significant associations in the AusDiab cohort (90%) were subsequently validated in the SAFHS cohort. The aberration of the plasma lipidome associated with type 2 diabetes is clearly present in prediabetes, prior to the onset of type 2 diabetes. Lipid classes and species associated with type 2 diabetes provide support for a number of existing paradigms of dyslipidemia and suggest new avenues of investigation.
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DOI：
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发表时间：
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影响因子：
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