Macrophage factor controlling differentiation of B cells.
Macrophage factor controlling differentiation of B cells.
复制标题
控制 B 细胞分化的巨噬细胞因子。
DOI：
10.4049/jimmunol.122.2.497
复制
发表时间：
1979
影响因子：
4.4
通讯作者：
U. Hammerling
中科院分区：
文献类型：
--
作者：
M. Hoffmann;S. Koenig;R. Mittler;H. Oettgen;P. Ralph;C. Galanos;U. Hammerling
小鼠腹腔巨噬细胞响应革兰氏阴性细菌的细胞壁成分（脂多糖和脂蛋白），产生一种因子，导致抗原刺激的 B 细胞分化为抗体产生细胞。与脂多糖不同，该因子对 B 细胞不具有促有丝分裂作用。巨噬细胞因子的产生不依赖于T细胞或其他辅助细胞的参与，因为它很容易由几种克隆的巨噬细胞系以及无胸腺裸鼠的腹膜巨噬细胞产生。该因子仅在与抗原结合时才具有活性。 T 细胞虽然显然不是必需的，但却可以增强其效果。该因子选择性地诱导 B 细胞前体的表型分化，就像胸腺生成素诱导前胸腺细胞的分化一样。
Peritoneal macrophages of the mouse produce, in response to cell wall components of Gram-negative bacteria (lipopolysaccharide and lipoproteins), a factor that causes antigen-stimulated B cells of differentiate into antibody-producing cells. Unlike lipopolysaccharide, this factor is not mitogenic for B cells. Production of the macrophage factor does not depend on participation of T cells or other accessory cells since it is readily produced by several cloned macrophage cell lines as well as by peritoneal macrophages of athymic nude mice. The factor is active only in conjunction with antigen. T cells, although apparently not necessary, amplify its effect. The factor induces phenotypic differentiation of B cell precursors as selectively as thymopoietin induces differentiation of prothymocytes.