Treatment of Alopecia Areata with Simvastatin/Ezetimibe.
Treatment of Alopecia Areata with Simvastatin/Ezetimibe.
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DOI:
10.1016/j.jisp.2017.10.013
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发表时间:
2018-01-01
期刊:
影响因子:
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通讯作者:
Tosti, Antonella
中科院分区:
文献类型:
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作者:
Cervantes, Jessica;Jimenez, Joaquin J;Tosti, Antonella
Alopecia areata (AA) is an autoimmune disorder characterized by T lymphocytic infiltrates around the bulbar region of hair follicles. Statins have surfaced as potential therapeutic agents for AA, partly because of their modulation of the JAK/STAT pathway. Some data indicate that statins are a possible option for acute, but not chronic, longstanding AA. Animal studies suggest that treatment with statins increases CD4+/CD25+/Foxp3+ populations in AA-affected mice.