Treatment of Alopecia Areata with Simvastatin/Ezetimibe.

Treatment of Alopecia Areata with Simvastatin/Ezetimibe.
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DOI:
10.1016/j.jisp.2017.10.013
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发表时间:
2018-01-01
期刊:
The journal of investigative dermatology. Symposium proceedings
影响因子:
--
通讯作者:
Tosti, Antonella
Tosti, Antonella
中科院分区:
其他
文献类型:
--
作者:
Cervantes, Jessica;Jimenez, Joaquin J;Tosti, Antonella

文献摘要

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斑秃 (AA) 是一种自身免疫性疾病,其特征是毛囊球部周围 T 淋巴细胞浸润。他汀类药物已成为 AA 的潜在治疗药物,部分原因是其对 JAK/STAT 通路的调节。一些数据表明,他汀类药物是治疗急性 AA 的可能选择,但不是慢性长期 AA 的选择。动物研究表明,他汀类药物治疗会增加 AA 影响小鼠的 CD4+/CD25+/Foxp3+ 数量。
Alopecia areata (AA) is an autoimmune disorder characterized by T lymphocytic infiltrates around the bulbar region of hair follicles. Statins have surfaced as potential therapeutic agents for AA, partly because of their modulation of the JAK/STAT pathway. Some data indicate that statins are a possible option for acute, but not chronic, longstanding AA. Animal studies suggest that treatment with statins increases CD4+/CD25+/Foxp3+ populations in AA-affected mice.