Frequency discrimination in rats exposed to noise as juveniles
Frequency discrimination in rats exposed to noise as juveniles
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DOI：
10.1016/j.physbeh.2015.03.005
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发表时间：
2015-05
影响因子：
2.9
通讯作者：
D. Šuta;N. Rybalko;D-W Shen;J. Popelář;P. Poon;J. Syka
中科院分区：
文献类型：
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作者：
D. Šuta;N. Rybalko;D-W Shen;J. Popelář;P. Poon;J. Syka
出生后早期的声暴露可显著影响大鼠成年后的听觉系统功能。在本研究中，大鼠幼仔（品系Long-Evans）暴露于125 dB SPL的宽带噪声8，12或25分钟，在出生后14天，然后在3-5个月的年龄在4和16 kHz的频率辨别使用的声惊吓反射的前脉冲抑制的改进的方法进行了评估。在所有暴露组大鼠中，与对照组相比，在70 dB SPL下观察到音调刺激的频率辨别力发生变化。即使在暴露8分钟的动物中也观察到频率辨别力的恶化，其听觉阈值与对照动物几乎相同。个体听阈与频率辨别力无相关性。在85-90 dB SPL时，暴露动物和对照动物之间的频率辨别力差异消失。我们的数据表明，短暂的噪声暴露在关键时期的发展结果在改变频率歧视在中等声音强度的成年大鼠，这可能会出现在个人正常的听力阈值。
Sound exposure during the early postnatal period can significantly influence the function of the auditory system in rats during adulthood. In the present study, rat pups (strain Long–Evans) were exposed to broad-band noise at 125 dB SPL for 8, 12 or 25 min on postnatal day 14 and then at the age of 3–5 months their frequency discrimination at 4 and 16 kHz was assessed using a modified method of the prepulse inhibition of the acoustic startle reflex. In all groups of exposed rats, an altered frequency discrimination of the tonal stimuli was observed, in comparison with controls, at 70 dB SPL. A worsening of frequency discrimination was observed even in animals exposed for 8 min, the auditory thresholds of which were almost identical to that of control animals. The individual auditory thresholds did not correlate with frequency discrimination. The difference in frequency discrimination between the exposed and control animals disappeared at 85–90 dB SPL. Our data suggests that brief noise exposure during the critical period of development results in the altered frequency discrimination at moderate sound intensities in adult rats, which may appear even in individuals with normal hearing thresholds.