An Efficient Copper‐Catalyzed Homocoupling of Terminal Alkynes to Give Symmetrical 1,4‐Disubstituted 1,3‐Diynes
An Efficient Copper‐Catalyzed Homocoupling of Terminal Alkynes to Give Symmetrical 1,4‐Disubstituted 1,3‐Diynes
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DOI：
10.1002/adsc.201100035
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发表时间：
2011-06
影响因子：
5.4
通讯作者：
Songlin Zhang;Xiaoyang Liu;Tongqiang Wang
中科院分区：
文献类型：
--
作者：
Songlin Zhang;Xiaoyang Liu;Tongqiang Wang
报道了一种在室温下，以空气为氧化剂，碘化铜和配体N，N，N '，N'-四甲基乙烷-1，2-二胺促进端炔均偶联反应的简便有效途径。炔类化合物，包括芳香族炔和脂肪族炔，都能以较高的产率合成对称的1，4-二取代1，3-二炔。
A facile and efficient pathway for the copper iodide and ligand N,N,N',N'-tetramethylethane-1,2-diamine promoted homocoupling reaction of terminal alkynes under ambient temperature and air as an oxidant was reported. The alkynes, including aromatic alkynes and aliphatic alkynes, could afford the symmetrical 1,4-disubstituted 1,3-diynes in good to excellent yields.