The induction of human superoxide dismutase and catalase in vivo: A fundamentally new approach to antioxidant therapy
The induction of human superoxide dismutase and catalase in vivo: A fundamentally new approach to antioxidant therapy
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DOI：
10.1016/j.freeradbiomed.2005.08.043
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发表时间：
2006-01-15
影响因子：
7.4
通讯作者：
McCord, JM
中科院分区：
文献类型：
--
作者：
Nelson, SK;Bose, SK;McCord, JM
将由五种广泛研究的药用植物（Protandim）的提取物组成的组合物给予年龄在20至78岁范围内的健康人受试者。根据已发表的啮齿类动物体内超氧化物歧化酶（SOD）和/或过氧化氢酶诱导结果，结合降低脂质过氧化的证据，选择单个成分。每种成分以足够低的剂量存在，以避免任何伴随的不必要的药理作用。在补充前以及补充30天和120天后（675 mg/天）分析血液。测定红细胞SOD和过氧化氢酶，测定血浆脂质过氧化产物硫代巴比妥酸反应物质（TBARS），以及尿酸，C-反应蛋白和胆固醇（总，LDL和HDL）。在补充之前，TBARS表现出强烈的年龄依赖性增加。补充30天后，TBARS平均下降了40%（p = 0.0001），年龄依赖性增加被消除。到120天时，红细胞SOD增加了30%（p < 0.01），过氧化氢酶增加了54%（p < 0.002）。我们的结论是，适度诱导的催化抗氧化剂SOD和过氧化氢酶可能是一个更有效的方法，比补充抗氧化剂（如维生素C和E），可以，最好的，化学计量的总氧化剂生产的一个非常小的部分。(c)2005年爱思唯尔公司All rights reserved.
A composition consisting of extracts of five widely studied medicinal plants (Protandim) was administered to healthy human subjects ranging in age from 20 to 78 years. Individual ingredients were selected on the basis of published findings of induction of superoxide dismutase (SOD) and/or catalase in rodents in vivo, combined with evidence of decreasing lipid peroxidation. Each ingredient was present at a dosage sufficiently low to avoid any accompanying unwanted pharmacological effects. Blood was analyzed before supplementation and after 30 and 120 days of supplementation (675 mg/day). Erythrocytes were assayed for SOD and catalase, and plasma was assayed for lipid peroxidation products as thiobarbituric acid-reacting substances (TBARS), as well as uric acid, C-reactive protein, and cholesterol (total, LDL, and HDL). Before supplementation, TBARS showed a strong age-dependent increase. After 30 days of supplementation, TBARS declined by an average of 40% (p = 0.0001) and the age-dependent increase was eliminated. By 120 days, erythrocyte SOD increased by 30% (p < 0.01) and catalase by 54% (p < 0.002). We conclude that modest induction of the catalytic antioxidants SOD and catalase may be a much more effective approach than supplementation with antioxidants (such as vitamins C and E) that can, at best, stoichiometrically scavenge a very small fraction of total oxidant production. (c) 2005 Elsevier Inc. All rights reserved.