Nucleus accumbens dopamine release reflects the selective nature of pair bonds.
Nucleus accumbens dopamine release reflects the selective nature of pair bonds.
复制标题
伏隔核多巴胺的释放反映了成对键的选择性性质。
DOI：
10.1016/j.cub.2023.12.041
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发表时间：
2024
期刊：
影响因子：
--
通讯作者：
Donaldson,ZoeR
中科院分区：
文献类型：
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作者：
Pierce,AnneF;Protter,DavidSW;Watanabe,YurikaL;Chapel,GabrielD;Cameron,RyanT;Donaldson,ZoeR
在一夫一妻制的物种中，针对伴侣的亲社会行为与针对未知个体和潜在威胁的亲社会行为截然不同。多巴胺释放在脑桥核在社会奖励和动机中有着明确的作用，但这种机制如何参与驱动针对伴侣或不熟悉的同种的高度分化的社会行为仍然是未知的。使用一夫一妻制的草原田鼠，我们首先采用受体药理学在合作伙伴的偏好和社会操作性任务表明，多巴胺是至关重要的社会互动的食欲驱动，但不是低努力，无条件的完善行为。然后，我们利用荧光生物传感器GRABDA的亚秒级时间分辨率来询问差异多巴胺释放是否可以区分伴侣和新的社交访问和互动。我们发现，寻找伴侣、期待和互动导致更多的多巴胺释放，而不是针对新田鼠的相同事件。此外，长期伴侣分离后，伴侣相关的多巴胺释放减少。我们的研究结果与多巴胺信号在社会互动的食欲方面发挥重要作用的模型一致。在这个框架内，在合作伙伴和小说相关的多巴胺释放的差异反映了对债券的选择性，并可能会推动合作伙伴和小说导向的社会行为，随着时间的推移，加强和水泥债券。这提供了一种潜在的机制，通过这种机制，高度保守的奖励系统可以实现选择性的、适合物种的社会行为。
In monogamous species, prosocial behaviors directed toward partners are dramatically different from those directed toward unknown individuals and potential threats. Dopamine release in the nucleus accumbens has a well-established role in social reward and motivation, but how this mechanism may be engaged to drive the highly divergent social behaviors directed at a partner or unfamiliar conspecific remains unknown. Using monogamous prairie voles, we first employed receptor pharmacology in partner preference and social operant tasks to show that dopamine is critical for the appetitive drive for social interaction but not for low-effort, unconditioned consummatory behaviors. We then leveraged the subsecond temporal resolution of the fluorescent biosensor, GRABDA, to ask whether differential dopamine release might distinguish between partner and novel social access and interaction. We found that partner seeking, anticipation, and interaction resulted in more accumbal dopamine release than the same events directed toward a novel vole. Further, partner-associated dopamine release decreased after prolonged partner separation. Our results are consistent with a model in which dopamine signaling plays a prominent role in the appetitive aspects of social interactions. Within this framework, differences in partner- and novel-associated dopamine release reflect the selective nature of pair bonds and may drive the partner- and novel-directed social behaviors that reinforce and cement bonds over time. This provides a potential mechanism by which highly conserved reward systems can enable selective, species-appropriate social behaviors.