Cortical sources of resting-state alpha rhythms are abnormal in persistent vegetative state patients
Cortical sources of resting-state alpha rhythms are abnormal in persistent vegetative state patients
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DOI：
10.1016/j.clinph.2009.02.157
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发表时间：
2009-04-01
影响因子：
4.7
通讯作者：
Rossini, Paolo Maria
中科院分区：
文献类型：
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作者：
Babiloni, Claudio;Sara, Marco;Rossini, Paolo Maria
目的：刺激前皮质 α 节律（约 8-12 HZ）的高强度是正常受试者意识知觉的基础。在这里，我们测试了这样的假设：持续性植物状态 (PVS) 患者的这些节律是异常的，这些患者是清醒的，但不知道自己和环境。方法：临床和静息状态、闭眼脑电图 (EEG) 数据取自临床档案。这些数据记录在 50 名 PVS 受试者（认知功能水平 - LCF 评分：I-II）和 30 名认知正常受试者中。感兴趣的节律是 delta (2-4 Hz)、theta (4-8 Hz)、alpha 1 (8-10.5 Hz)、alpha 2 (10.5-13 Hz)、beta 1 (13-20 Hz) 和 beta 2 (20-30 Hz)。通过低分辨率电磁断层扫描（LORETA）估计皮质源。根据 3 个月随访时的 LCF 评分，将 PVS 患者回顾性分为三组：30 名未恢复的受试者（NON-REC 患者；随访 LCF：I-II）、8 名被归类为最低意识状态患者（MCS 患者；随访 LCF：III-IV）和 12 名康复受试者（REC 患者；随访 LCF：V-VIII）。 α2 在正常受试者中较高，在 REC 患者中较低，在非 REC 患者中几乎为零。 Cox回归分析表明，alpha Source的功效预测了后续恢复的速度，即其功效越高。恢复意识的机会就越高。此外，MCS 患者的枕叶 α 源功率显示出 REC 和非 REC 患者之间的中间值。结论：这些结果表明，皮质 α 节律源与持续植物人状态患者 3 个月随访时恢复的机会相关。意义：静息 α 节律的皮质源可能预测 PVS 患者的恢复。 (C) 2009 年国际临床神经生理学联合会。由爱思唯尔爱尔兰有限公司出版。保留所有权利。
Objective: High power of pre-stimulus cortical alpha rhythms (about 8-12 HZ) underlies conscious perception in normal subjects. Here we tested the hypothesis that these rhythms are abnormal in persistent vegetative state (PVS) patients, who are awake but not aware of self and environment.Methods: Clinical and resting-state, eyes-closed electrorencephalographic (EEG) data were taken from a clinical archive. These data were recorded in 50 PVS subjects (level of cognitive functioning - LCF score: I-II) and in 30 cognitively normal subjects. Rhythms of interest were delta (2-4 Hz), theta (4-8 Hz), alpha 1 (8-10.5 Hz), alpha 2 (10.5-13 Hz), beta 1 (13-20 Hz), and beta 2 (20-30 Hz). Cortical sources were estimated by low-resolution electromagnetic tomography (LORETA). Based on LCF score at 3-months follow-up, PVS patients were retrospectively divided into three groups: 30 subjects who did not recover (NON-REC patients; follow-up LCF: I-II), 8 Subjects classified as minimally conscious state patients (MCS patients; follow-up LCF: III-IV), and 12 subjects who recovered (REC patients; follow-up LCF: V-VIII).Results: Occipital Source power of alpha I and alpha 2 was high in normal subjects, low in REC patients, and practically null in NON-REC patients. A Cox regression analysis showed that the power of alpha Source predicted the rate of the follow up recovery, namely the higher its power. the higher the chance to recover consciousness. Furthermore, the MCS patients showed intermediate values of occipital alpha Source power between REC and NON-REC patients.Conclusions: These results Suggest that cortical sources of alpha rhythms are related to the chance of recovery at a 3-months follow-up in patients in persistent vegetative state.Significance: Cortical sources of resting alpha rhythms might predict recovery in PVS patients. (C) 2009 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.