A series of novel indazole derivatives of Sirt 1 activator as osteogenic regulators
A series of novel indazole derivatives of Sirt 1 activator as osteogenic regulators
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DOI：
10.1016/j.bmcl.2017.09.049
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发表时间：
2017-11-01
影响因子：
2.7
通讯作者：
Arai, Hirokazu
中科院分区：
文献类型：
--
作者：
Atobe, Masakazu;Yamakawa, Natsumi;Arai, Hirokazu
通过高通量筛选，一系列吲唑衍生物被鉴定为Sirt 1激活剂。吲唑环上的每个取代基的优化导致化合物13的鉴定。化合物13似乎给出了测试化合物中最好的Sirt 1活性，并且在细胞测定中也显示出骨生成活性。因此，Sirt 1激活剂是（C）2017 Elsevier Ltd.治疗的潜在候选药物。保留所有权利。
A series of indazole derivatives were identified as Sirt 1 activators though high-throughput screening. Optimization of each substituent on the indazole ring led to the identification of compound 13. Compound 13 appeared to give the best Sirt 1 activity of the compounds tested and also showed osteogenesis activity in a cell assay. Sirt 1 activators are therefore potential candidates for the treatment of (C) 2017 Elsevier Ltd. All rights reserved.