ANTIBODIES AGAINST CRYSTALS
ANTIBODIES AGAINST CRYSTALS
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DOI：
10.1096/fasebj.6.8.1592211
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发表时间：
1992-05-01
期刊：
影响因子：
4.8
通讯作者：
ADDADI, L
中科院分区：
文献类型：
--
作者：
KAM, M;PERLTREVES, D;ADDADI, L
我们认为，晶体，当被引入到一个有机体，可能会表现为传统的抗原，介导的特定抗体的生产。这些抗体将带有晶体表面的印记，因此可以在新的结晶事件中表现为成核基质。因此，它们将表现为催化抗体。我们表明，从患有痛风的患者中分离的IgG抗体，痛风是一种由一水异戊尿酸盐（MSUM）晶体引起的关节疾病，加速了体外盐的过饱和溶液中MSUM新晶体的出现。对于从患有其他关节疾病（如假性痛风、类风湿性关节炎或骨关节炎）的患者的关节液中分离的IgG抗体，未观察到相同的效果。此外，从皮下注射MSUM晶体的兔获得的IgG抗体也朝向MSUM晶体成核。
We suggest that crystals, when introduced into an organism, may behave as conventional antigens, mediating the production of specific antibodies. These antibodies would bear an imprint of the crystal surface and may consequently behave as a nucleating matrix in a new crystallization event. Thus, they would behave as catalytic antibodies. We show that IgG antibodies isolated from patients suffering from gout, a joint disease caused by crystals of monosodium urate monohydrate (MSUM), accelerate the appearance of new crystals of MSUM from a supersaturated solution of the salt in vitro. The same effect is not observed for IgG antibodies isolated from the joint fluids of patients with other joint diseases, such as pseudogout, rheumatoid arthritis, or osteoarthritis. Furthermore, IgG antibodies obtained from rabbits injected subcutaneously with crystals of MSUM, were also nucleating towards MSUM crystals.