Marked regional heterogeneity in the magnitude of EDRF/NO-mediated vascular tone in awake rats.
Marked regional heterogeneity in the magnitude of EDRF/NO-mediated vascular tone in awake rats.
复制标题
清醒大鼠中 EDRF/NO 介导的血管张力强度存在明显的区域异质性。
DOI：
10.1097/00005344-199302000-00008
复制
发表时间：
1993
影响因子：
3
通讯作者：
Longnecker,DE
中科院分区：
文献类型：
--
作者：
Greenblatt,EP;Loeb,AL;Longnecker,DE
在清醒的消炎痛处理的大鼠上，研究了抑制内皮源性松弛因子/一氧化氮(EDRF/NO)对全身和局部血流动力学的影响。用放射标记微球法测定12个组织在给予EDRF/NO合成抑制剂N-单甲基-L-精氨酸(NMMA，10 0 mg/kg)前后和用L精氨酸(30 0 mg/kg)逆转NMMA前后的心输出量、全身血管阻力、局部血流量和局部血管阻力。NMMA输注后血压升高，SVR升高。NMMA后，流向大脑、心脏、肾脏、脾、胃肠道、皮肤、耳朵和白色脂肪的血流量减少，而肝动脉的血流量增加。除肝动脉外，所有研究组织的血管阻力均增加，NMMA后阻力降低。L-精氨酸使12个组织中的8个组织的血管阻力恢复到对照水平。在所研究的器官中，区域阻力增加的幅度并不均匀，从棕色脂肪中的最大值253%到心脏中的22%不等。这些结果表明，在正常大鼠的许多组织中，EDRF/NO是局部血流动力学控制的重要介质。基础EDRF/NO依赖音调的显著异质性表明，调节这一心血管控制系统的机制是局部调节的。
The systemic and regional hemodynamic effects of inhibition of endothelium-derived relaxing factor/nitric oxide (EDRF/NO) were studied in awake, indo-methacin-treated rats. The radiolabeled microsphere method was used to determine the cardiac output, systemic vascular resistance (SVR), and regional blood flows and regional vascular resistances in 12 tissues before and after infusion of the EDRF/NO synthesis inhibitor, N G-monomethyl-L-arginine (NMMA, 100 mg/kg), and after reversal of NMMA by infusion of L-arginine (300 mg/kg). NMMA infusion resulted in increases in the blood pressure and SVR. After NMMA, blood flows were decreased to the cerebrum, heart, kidney, spleen, gastrointestinal tract, skin, ear, and white fat, whereas flow in the hepatic artery was increased. Vascular resistances were increased in every tissue studied except the hepatic artery, in which the resistance decreased after NMMA. L-arginine restored the vascular resistance to control values in 8 of the 12 tissues. The magnitude of the increase in the regional resistance was not uniform among the organs studied, and ranged from a maximum of 253% in brown fat to 22% in heart. These results indicate that EDRF/NO is an important mediator of regional hemodynamic control in numerous tissues of the intact rat. The marked heterogeneity in the magnitude of basal EDRF/NO-dependent tone suggests that the mechanisms mediating this cardiovascular control system are regulated locally.