Factors that influence the outcome of primary pulmonary hypertension.
Factors that influence the outcome of primary pulmonary hypertension.
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影响原发性肺动脉高压结果的因素。
DOI：
10.1136/hrt.55.5.449
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发表时间：
1986
影响因子：
--
通讯作者：
C. Oakley
中科院分区：
文献类型：
--
作者：
A. Rozkovec;P. Montañes;C. Oakley
预测原发性肺动脉高压患者预期寿命的因素尚未明确。回顾性分析了34例随访至死亡或至少5年的原发性肺动脉高压病例。患者被分为三组：18名患者在入院后5年内死亡; 12名患者存活超过5年; 4名患者病情好转并存活超过5年。三组的发病年龄相似，与症状和性别一样，不能预测预期寿命。在疾病过程中右心衰竭与不良结局相关。心脏增大的放射学证据和心电图上右心劳损的证据也预测生存少于5年。存活时间最短者肺小动脉阻力较高，心输出量较低。肺动脉压与生存时间无相关性。体循环阻力与肺循环阻力直接相关，维持体循环压力。妊娠期或妊娠后的表现以及卵圆孔的开放与较长的生存期相关。在4例患者中，有证据表明心脏导管插入术和肺组织学检查显示疾病消退。原发性肺动脉高压是一种异质性疾病，其预期寿命差异很大。
Factors predicting life expectancy in primary pulmonary hypertension have not been well defined. Thirty four cases of primary pulmonary hypertension that had been followed up until death or for at least five years were reviewed retrospectively. Patients were divided into three groups: 18 patients who died within five years of presentation to hospital; 12 who survived more than five years; and four who improved and who lived for more than five years. The age at onset was similar in the three groups and, like symptoms and sex, did not predict life expectancy. Right heart failure during the course of the disease was associated with a poor outcome. Radiographic evidence of cardiac enlargement and evidence of right heart strain on electrocardiogram at presentation was also predictive of survival for less than five years. Pulmonary arteriolar resistance was higher and cardiac output lower in those with the shortest survival times. There was no relation between pulmonary artery pressure and length of survival. Systemic resistance varied directly with pulmonary resistance and served to maintain systemic pressure. Presentation in or after pregnancy and patency of the foramen ovale were associated with longer survival. In four patients there was evidence of regression of the disease by cardiac catheterisation and lung histology. Primary pulmonary hypertension is a heterogeneous condition in which life expectancy varies widely.
硝苯地平治疗原发性肺动脉高压。
影响因子：
39.2
作者：
Rubin,LJ;Nicod,P;Hillis,LD;Firth,BG
通讯作者：
Firth,BG
家族性原发性肺动脉高压：临床模式。
DOI：
10.1164/arrd.1984.129.1.194
发表时间：
1984
期刊：
The American review of respiratory disease
影响因子：
--
作者：
Loyd,JE;Primm,RK;Newman,JH
通讯作者：
Newman,JH