Neurologic effects of manganese in humans: A review
Neurologic effects of manganese in humans: A review
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DOI：
10.1179/oeh.2003.9.2.153
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发表时间：
2003-04-01
影响因子：
--
通讯作者：
Nassetta, WJ
中科院分区：
文献类型：
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作者：
Levy, BS;Nassetta, WJ
锰主要通过吸入进入人体，会损害神经系统和呼吸道，以及其他不良影响。职业接触主要发生在采矿、合金生产、加工、铁锰作业、焊接和使用农用化学品的工作。在神经系统的影响是一个不可逆的帕金森样综合征。据估计，美国有50万至150万人患有帕金森病，医生需要在其鉴别诊断中考虑锰暴露。自1837年以来，有许多病例和病例系列报告描述了锰中毒。最近，有流行病学研究其对健康的不利影响。职业医学医生可以在预防锰对健康的不良影响方面发挥关键作用。
Manganese, which enters the body primarily via inhalation, can damage the nervous system and respiratory tract, as well as have other adverse effects. Occupational exposures occur mainly in mining, alloy production, processing, ferro-manganese operations, welding, and work with agrochemicals. Among the neurologic effects is an irreversible parkinsonian-like syndrome. An estimated 500,000 to 1.5 million people in the United States have Parkinson's disease, and physicians need to consider manganese exposure in its differential diagnosis. Since 1837, there have been many reports of cases and case series describing manganese toxicity. More recently, there have been epidemiologic studies of its adverse effects on health. Occupational medicine physicians can play critical roles in preventing the adverse health effects of manganese.