Executive function and PTSD: disengaging from trauma.
Executive function and PTSD: disengaging from trauma.
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DOI：
10.1016/j.neuropharm.2011.02.008
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发表时间：
2012-02
影响因子：
4.7
通讯作者：
Paulus MP
中科院分区：
文献类型：
--
作者：
Aupperle RL;Melrose AJ;Stein MB;Paulus MP
神经心理学方法是识别与创伤后应激障碍（PTSD）症状发展和维持相关的易感性和弹性因素的重要途径。本综述将总结前瞻性纵向和回顾性横断面研究的结果，调查与PTSD相关的执行功能。本研究特别指出，在创伤暴露之前，反应抑制和注意力调节方面的细微损伤可能是PTSD发展的危险因素，并与症状的严重程度有关。这些损伤可能在情绪或创伤相关的情况下加剧，并可能与背前额叶网络的功能障碍有关。本文提出了一个模型，说明这些损伤如何导致PTSD的临床特征，并导致使用其他应对方式，如回避。需要进一步的神经心理学研究来确定治疗对认知功能的影响，并潜在地描述当前创伤后应激障碍治疗的机制。从认知和神经科学研究中获得的知识可能对未来开发新的、更有效的创伤后应激障碍治疗方法有价值。
Neuropsychological approaches represent an important avenue for identifying susceptibility and resiliency factors relating to the development and maintenance of posttraumatic stress disorder (PTSD) symptoms post-trauma. This review will summarize results from prospective longitudinal and retrospective cross-sectional studies investigating executive function associated with PTSD. This research points specifically towards subtle impairments in response inhibition and attention regulation that may predate trauma exposure, serve as risk factors for the development of PTSD, and relate to the severity of symptoms. These impairments may be exacerbated within emotional or trauma-related contexts, and may relate to dysfunction within dorsal prefrontal networks. A model is presented concerning how such impairments may contribute to the clinical profile of PTSD and lead to the use of alternative coping styles such as avoidance. Further neuropsychological research is needed to identify the effects of treatment on cognitive function and to potentially characterize mechanisms of current PTSD treatments. Knowledge gained from cognitive and neuroscientific research may prove valuable for informing the future development of novel, more effective, treatments for PTSD.