Antibacterial activity of aminals and hemiaminals of pyrazole and imidazole
Antibacterial activity of aminals and hemiaminals of pyrazole and imidazole
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DOI：
10.1007/s00044-011-9839-2
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发表时间：
2012-10-01
影响因子：
2.6
通讯作者：
Iovu, Mircea
中科院分区：
文献类型：
--
作者：
Lupsor, Simona;Aonofriesei, Florin;Iovu, Mircea
采用扩散法和肉汤稀释法测定了1,1′-亚甲二吡唑（AM1）、1-羟甲基吡唑（SAM1）、1,1′-亚甲二咪唑（AM2）和1-羟甲基咪唑（SAM2）对对照菌和临床菌株的抑菌活性。总的来说，被试化合物的最小抑菌浓度在180 ~ 270 μ g/ml之间，而最小杀菌浓度在360 ~ 720 μ g/ml之间。与苯酚和甲醛的对比评价表明，AM1、AM2、SAM1和SAM2具有中等至良好的抗菌活性。
Antibacterial activity of 1,1'-methylenedipyrazole (AM1), 1-hydroxymethylpyrazole (SAM1), 1,1'-methylenediimidazole (AM2), and 1-hydroxymethylimidazole (SAM2) has been tested against reference and clinical strains by both difusimetric and broth dilution methods. Overall, the minimal inhibitory concentrations of tested compounds ranged from 180 to 270 mu g/ml, while the minimal bactericidal concentrations were between 360 and 720 mu g/ml. Comparative assessment with phenol and formaldehyde shows that AM1, AM2, SAM1, and SAM2 have moderate to good antibacterial activity.