Sensing, physiological effects and molecular response to elevated CO2 levels in eukaryotes.
Sensing, physiological effects and molecular response to elevated CO2 levels in eukaryotes.
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DOI：
10.1111/j.1582-4934.2009.00952.x
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发表时间：
2009-11
影响因子：
5.3
通讯作者：
Gruenbaum Y
中科院分区：
文献类型：
--
作者：
Sharabi K;Lecuona E;Helenius IT;Beitel GJ;Sznajder JI;Gruenbaum Y
二氧化碳（CO2）是维持生物圈稳态的重要气体分子，也是所有生物体中重要的细胞信号分子。CO2通过膜的运输在植物和动物生命的最基本方面都起着重要作用。人们越来越感兴趣的是了解CO2是如何被运输到细胞中的，它是如何被神经元和其他细胞类型感知的，以及在细胞和生物体水平上了解CO2水平升高（高碳酸血症）的生理和分子后果。人类肺部疾病和模式生物，如真菌，C。线虫、果蝇和小鼠的CO2感受和响应机制的研究已被证明是重要的。
Carbon dioxide (CO2) is an important gaseous molecule that maintains biosphere homeostasis and is an important cellular signalling molecule in all organisms. The transport of CO2 through membranes has fundamental roles in most basic aspects of life in both plants and animals. There is a growing interest in understanding how CO2 is transported into cells, how it is sensed by neurons and other cell types and in understanding the physiological and molecular consequences of elevated CO2 levels (hypercapnia) at the cell and organism levels. Human pulmonary diseases and model organisms such as fungi, C. elegans, Drosophila and mice have been proven to be important in understanding of the mechanisms of CO2 sensing and response.