Frontostriatal and behavioral adaptations to daily sugar-sweetened beverage intake: a randomized controlled trial
Frontostriatal and behavioral adaptations to daily sugar-sweetened beverage intake: a randomized controlled trial
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DOI：
10.3945/ajcn.116.140145
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发表时间：
2017-03-01
影响因子：
7.1
通讯作者：
Burger, Kyle S.
中科院分区：
文献类型：
--
作者：
Burger, Kyle S.
背景：目前的肥胖理论表明，反复摄入高美味的高糖食物会导致纹状体、顶叶以及大脑中的前额叶和视觉皮质的适应，这可能有助于以前馈方式持续摄入。目的：我们测试了经常摄入含糖饮料对大脑和对饮料刺激的行为反应的影响。设计：我们对20名健康体重的人进行了实验，他们被随机分配到每天饮用2种含糖饮料中的一种，连续21天，接受2次功能磁共振检查，并完成了行为和显性享乐学评估。结果：与临床前实验一致，日常饮品导致接受饮品时的背侧纹状体反应减少(r=-0.46)，在商标引发的预期期间减少腹内侧额前额叶反应(r=-0.44)。这种前额叶反应的减少与对所消费饮料标识的行为去抑制的增加相关(r=0.54；P=0.02)。与无味的对照相比，日常饮用的饮料也增加了对这两个果汁标识的楔前反应(r=0.45)，这表明对饮料提示的影响更普遍。最后，重复饮用一种饮料导致了类似的未消费饮料的明显的享乐主义贬值(P<；0.001)。结论：与以前的报道类似，这些初步结果为经常摄入含糖饮料在改变对经常消费的饮料的神经行为反应中的作用提供了趋同的数据，这种作用也可能延伸到其他饮料刺激。未来的研究需要在更大的样本中提供复制的证据，并确定这里观察到的神经行为适应是高糖和/或非营养甜味饮料所特有的，还是更普遍地与重复食用任何类型的食物有关。
Background: Current obesity theories suggest that the repeated intake of highly palatable high-sugar foods causes adaptions in the striatum, parietal lobe, and prefrontal and visual cortices in the brain that may serve to perpetuate consumption in a feed-forward manner. However, the data for humans are cross-sectional and observational, leaving little ability to determine the temporal precedence of repeated consumption on brain response.Objective: We tested the impact of regular sugar-sweetened beverage intake on brain and behavioral responses to beverage stimuli.Design: We performed an experiment with 20 healthy-weight individuals who were randomly assigned to consume 1 of 2 sugar-sweetened beverages daily for 21 d, underwent 2 functional MRI sessions, and completed behavioral and explicit hedonic assessments.Results: Consistent with preclinical experiments, daily beverage consumption resulted in decreases in dorsal striatal response during receipt of the consumed beverage (r = -0.46) and decreased ventromedial prefrontal response during logo-elicited anticipation (r = -0.44). This decrease in the prefrontal response correlated with increases in behavioral disinhibition toward the logo of the consumed beverage (r = 0.54; P = 0.02). Daily beverage consumption also increased precuneus response to both juice logos compared with a tasteless control (r = 0.45), suggesting a more generalized effect toward beverage cues. Last, the repeated consumption of 1 beverage resulted in an explicit hedonic devaluation of a similar nonconsumed beverage (P < 0.001).Conclusions: Analogous to previous reports, these initial results provide convergent data for a role of regular sugar-sweetened beverage intake in altering neurobehavioral responses to the regularly consumed beverage that may also extend to other beverage stimuli. Future research is required to provide evidence of replication in a larger sample and to establish whether the neurobehavioral adaptations observed herein are specific to high-sugar and/or nonnutritive-sweetened beverages or more generally related to the repeated consumption of any type of food.