Altered energy metabolism after myocardial infarction assessed by 31P-MR-spectroscopy in humans
Altered energy metabolism after myocardial infarction assessed by 31P-MR-spectroscopy in humans
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DOI：
10.1007/s003300000316
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发表时间：
2000-01-01
影响因子：
5.9
通讯作者：
Hahn, D
中科院分区：
文献类型：
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作者：
Beer, M;Sandstede, J;Hahn, D
分析了人类心肌梗死后p -31磁共振波谱（MRS）作为区分活组织和非活组织的可能工具的价值。对15例前路心肌梗死后3周的患者进行屏气MRI和3D-CSI MRS （1.5 T系统）研究。从梗死和非梗死心肌中获得p -31谱（每个体素大小为25cm(3)）。生存能力的金标准是在血运重建术后6个月通过对照MRI确定的区域功能恢复。10名年龄相匹配的健康志愿者作为对照组。两组间无显著差异；磷酸肌酸与三磷酸腺苷（PCr/ATP）比值（SD = 1.72 +/- 0.31）和患者无梗死间隔心肌。Cine MRI显示10例患者局部功能恢复，即10例显示存活心肌，5例显示不存活心肌。在存活心肌中，PCr/ATP比值为1.47 +/- 0.38（与志愿者相比无统计学意义；p < 0.05）。在5例心肌不动患者中，未检测到PCr峰。因此，无法计算PCr/ATP比值。然而，观察到ATP信噪比（SNR）显著降低(2.92 +/- 0.73 vs 6.68 +/- 0.80；患者vs志愿者；p
The value of P-31-magnetic resonance spectroscopy (MRS) as a possible tool to distinguish viable from non-viable tissue after myocardial infarction was analysed in humans. Fifteen patients 3 weeks after anterior myocardial infarction were studied with breath-hold cine MRI and 3D-CSI MRS (1.5 T system). P-31-spectra were obtained from infarcted as well as non-infarcted myocardium (voxel size 25 cm(3) each). Gold standard for viability was recovery of regional function, as determined by a control MRI 6 months after revascularization. Ten age matched healthy volunteers served as control group. No significant difference was found between the; phosphocreatine to adenosinetriphosphate (PCr/ATP) ratio of volunteers (SD 1.72 +/- 0.31) and non-infarcted septal myocardium of patients. Cine MRI demonstrated recovery of regional function in 10 patients, i.e. 10 patients showed viable and 5 non-viable myocardium. In viable myocardium, the PCr/ATP ratio was 1.47 +/- 0.38 (non-significant vs volunteers; p > 0.05). In the 5 patients with akinetic myocardium, PCr peaks could not be detected. Therefore, calculation of PCr/ATP ratios was not possible. However, a significant reduction of the ATP signal-to-noise ratio (SNR) was observed (2.92 +/- 0.73 vs 6.68 +/- 0.80; patients vs volunteers; p