The role of matrix metalloproteinases in glioma invasion
The role of matrix metalloproteinases in glioma invasion
复制标题
DOI：
10.2741/1016
复制
发表时间：
2003-01-01
期刊：
影响因子：
--
通讯作者：
Yamashita, J
中科院分区：
文献类型：
--
作者：
Nakada, M;Okada, Y;Yamashita, J
基质金属蛋白酶(MMP)家族在多种生理和病理条件下对细胞外基质(ECM)的降解起着重要作用。越来越多的证据表明，MMPs通过细胞表面ECM降解促进癌细胞对周围正常组织的侵袭和转移。据报道，在人脑胶质瘤中，升高的基质金属蛋白酶水平与肿瘤细胞侵袭性之间存在很强的相关性。其中，明胶酶(MMP2和MMP9)和膜型MMPs(MT-MMPs)已成为研究热点。我们在这里讨论这些MMPs在胶质母细胞瘤侵袭过程中的生物学意义。更好地了解细胞-ECM的相互作用将有助于制定治疗策略，以降低胶质瘤的侵袭性。
The matrix metalloproteinase (MMP) family plays an important role in the degradation of extracellular matrix (ECM) in various physiological and pathological conditions. Accumulated evidence has suggested that MMPs contribute to cancer cell invasion of the surrounding normal tissues and metastasis through the cell-surface ECM degradation. Strong correlations have been reported between elevated MMP levels and tumor cell invasiveness in human gliomas. Among them, attention has been focused on gelatinases (MMP-2 and MMP-9) and membrane type MMPs (MT-MMPs). We discuss here the biological significance of these MMPs in the glioblastoma invasion processes. A better understanding of cell-ECM interactions will help in developing therapeutic strategies to decrease the invasion of gliomas.