Management of Childhood Onset Nephrotic Syndrome
Management of Childhood Onset Nephrotic Syndrome
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DOI：
10.1542/peds.2008-1559
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发表时间：
2009-08-01
期刊：
影响因子：
8
通讯作者：
Greenbaum, Larry A.
中科院分区：
文献类型：
--
作者：
Gipson, Debbie S.;Massengill, Susan F.;Greenbaum, Larry A.
儿童肾病综合征的治疗方法基于一系列研究，这些研究始于1967年由国际儿童肾脏疾病研究组织发起的国际合作努力。近几十年来，以肾病综合征为表现的儿童的特征发生了变化，具有挑战性的局灶节段性肾小球硬化症的发生率更高，肥胖和糖尿病的患病率更高，前者可能对糖皮质激素有抵抗性，后两种情况下可能因长期糖皮质激素治疗而加剧。儿童肾病综合征共识会议的成立是为了系统地回顾已发表的文献，并制定儿童原发性肾病综合征指南，以供教育、治疗和研究场所使用。儿科2009;[124] 747- 757
The therapeutic approach to childhood nephrotic syndrome is based on a series of studies that began with an international collaborative effort sponsored by the International Study of Kidney Disease in Children in 1967. The characteristics of children presenting with nephrotic syndrome have changed over recent decades with greater frequency of the challenging condition focal segmental glomerulosclerosis and a greater prevalence of obesity and diabetes mellitus, which may be resistant to glucocorticoids in the former and exacerbated by longterm glucocorticoid therapy in the latter 2 conditions. The Children's Nephrotic Syndrome Consensus Conference was formed to systematically review the published literature and generate a children's primary nephrotic syndrome guideline for use in educational, therapeutic, and research venues. Pediatrics 2009; 124: 747- 757