Western Equine Encephalitis submergence: Lack of evidence for a decline in virus virulence
Western Equine Encephalitis submergence: Lack of evidence for a decline in virus virulence
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DOI：
10.1016/j.virol.2008.08.012
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发表时间：
2008-10-25
期刊：
影响因子：
3.7
通讯作者：
Weaver, Scott C.
中科院分区：
文献类型：
--
作者：
Forrester, Naomi L.;Kenney, Joan L.;Weaver, Scott C.
人类和马科动物的西部马脑炎 (WEE) 发病率在 20 世纪中叶达到顶峰，在过去 20 年中已降至每年不到 1-2 例人类病例。使用小鼠模型，研究了 WEE 病毒 (WEEV) 毒力的变化，作为病例数量下降的潜在解释。对代表不同分离地点、宿主以及从 1940 年代到 1990 年代的所有几十年的 10 种 WEEV 毒株的评估没有发现毒力下降的证据。这些结果表明，应研究影响人类和马暴露的生态因素，以解释 WEE 的下降。 (C) 2008 Elsevier Inc. 保留所有权利。
The incidence of Western Equine Encephalitis (WEE) in humans and equids peaked during the mid-20th century and has declined to fewer than 1-2 human cases annually during the past 20 years. Using the mouse model, changes in WEE virus (WEEV) virulence were investigated as a potential explanation for the decline in the number of cases. Evaluation of 10 WEEV strains representing a variety of isolation locations, hosts, and all decades from the 1940's to the 1990's yielded no evidence of a decline in virulence. These results suggest that ecological factors affecting human and equine exposure should be investigated to explain the decline in WEE. (C) 2008 Elsevier Inc. All rights reserved.