Diversity of Metabotropic Glutamate Receptor-Interacting Proteins and Pathophysiological Functions
Diversity of Metabotropic Glutamate Receptor-Interacting Proteins and Pathophysiological Functions
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DOI：
10.1007/978-3-7091-0932-8_3
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发表时间：
2012-01-01
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影响因子：
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通讯作者：
Fagni, Laurent
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文献类型：
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作者：
Fagni, Laurent
在哺乳动物大脑中，绝大多数兴奋性突触表达突触前和突触后谷氨酸受体。这些是离子通道和G蛋白偶联膜蛋白，它们被组织成功能性信号复合物。在这里，我们将回顾与这些受体相关的支架蛋白的性质和病理生理功能，重点是G蛋白偶联亚型。
In the mammalian brain, the large majority of excitatory synapses express pre- and postsynaptic glutamate receptors. These are ion channels and G protein-coupled membrane proteins that are organized into functional signaling complexes. Here, we will review the nature and pathophysiological functions of the scaffolding proteins associated to these receptors, focusing on the G protein-coupled subtypes.