The tensile properties of alginate hydrogels
The tensile properties of alginate hydrogels
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DOI：
10.1016/j.biomaterials.2003.10.002
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发表时间：
2004-07-01
期刊：
影响因子：
14
通讯作者：
Mooney, DJ
中科院分区：
文献类型：
--
作者：
Drury, JL;Dennis, RG;Mooney, DJ
海藻酸盐水凝胶目前正在广泛的医疗应用中使用和探索，包括细胞封装、药物输送……和组织工程。在这些能力中，了解水凝胶的机械和材料特性以及控制和影响它们的特性对于充分设计和有效使用这些系统是必要的。尽管人们对海藻酸盐在压缩和剪切方面的机械性能了解甚多，但对其拉伸特性却知之甚少。因此，根据藻酸盐类型、配方、胶凝条件、孵育和应变率，完成了对藻酸盐水凝胶的广泛拉伸评估。一般来说，海藻酸盐水凝胶的初始拉伸行为和性能高度依赖于海藻酸盐聚合物的选择及其加工方式。具体而言，含有高古洛糖醛酸的藻酸盐聚合物产生比含有高甘露糖醛酸的藻酸盐更强、更具延展性的水凝胶。通过增加磷酸盐浓度、用磷酸盐缓冲盐水代替培养基重构溶液以及肽修饰，最终应力、极限应变和拉伸模量均降低。水凝胶孵育至少 7 天可以减少许多与配方和胶凝条件相关的初始拉伸性能差异。总的来说，通过控制特定的藻酸盐聚合物和加工方法，这些水凝胶可以获得广泛的拉伸性能。 (C) 2003 Elsevier Ltd. 保留所有权利。
Alginate hydrogels are currently being employed and explored for a broad range of medical applications including cell encapsulation, drug delivery.. and tissue engineering. In these capacities, knowledge of the mechanical and material properties of the hydrogels and the properties that govern and influence them is necessary to adequately design and effectively use these systems. Although much is known about the mechanical properties of alginate in compression and shear, little is known about the tensile characteristics. Thus, an extensive tensile assessment of alginate hydrogels was completed as a function of alginate type, formulation, gelling conditions, incubation, and strain rate. In general, the initial tensile behavior and properties of alginate hydrogels were highly dependent on the choice of the alginate polymer and how it was processed. Specifically, high guluronic acid containing alginate polymers yielded stronger, more ductile hydrogels than high mannuronic acid containing alginates. The ultimate stress, ultimate strain, and tensile modulus were decreased by increased phosphate concentrations, solution reconstitution with phosphate buffered saline instead of culture media, and peptide modification. Incubation of hydrogels for at least 7 days diminished many of the initial tensile property differences associated with formulation and gelling conditions. Overall, by controlling the specific alginate polymer and processing methods, a wide range of tensile properties are available from these hydrogels. (C) 2003 Elsevier Ltd. All rights reserved.