A CASE-CONTROL STUDY OF DEMENTIA OF THE ALZHEIMER TYPE
A CASE-CONTROL STUDY OF DEMENTIA OF THE ALZHEIMER TYPE
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DOI：
10.1093/oxfordjournals.aje.a114013
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发表时间：
1985-01-01
影响因子：
5
通讯作者：
CHRISTIANS, B
中科院分区：
文献类型：
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作者：
FRENCH, LR;SCHUMAN, LM;CHRISTIANS, B
一项病例对照研究对 1979 年至 1982 年在美国明尼苏达州明尼阿波利斯退伍军人管理局医疗中心诊断的 78 例男性病例以及年龄、种族、性别匹配的医院和社区对照进行了一项病例对照研究，以评估对阿尔茨海默型痴呆可能具有病因学意义的因素（16 例尸检病例中的 14 例得到组织病理学证实）。获得了与病毒、遗传和免疫学假设相关的变量以及可能的职业和环境暴露、吸毒、心理压力、吸烟和饮酒的信息。阿尔茨海默型痴呆患者与对照组之间的唯一主要区别是患者先前发生头部外伤的发生率明显更高（比值比 = 4.50）。这一发现与创伤后痴呆的文献一致，但其重要性目前尚不清楚。
A case-control study to assess factors of possible etiologic significance to dementia of the Alzheimer type was conducted with 78 male cases diagnosed in 1979-1982 at the Veternas Administration Medical Center in Minneapolis, Minnesota [USA] and age-race-sex-matched hospital and neighborhood controls (14 of 16 autopsied cases were histopathologically confirmed). Information was obtained on variables relevant to viral, genetic and immunologic hypotheses, and on possible occupational and environmental exposures, drug use, psychologic stress, smoking and alcohol consumption. The only major difference between patients with dementia of the Alzheimer type and controls was a significantly greater occurrence of antecedent head trauma in the patients (odds ratio = 4.50). This finding is consistent with the literature on posttraumatic dementia but its importance is presently unclear.