Thymine Dimers and Inhibition of DNA Synthesis by Ultraviolet Irradiation of Cells
Thymine Dimers and Inhibition of DNA Synthesis by Ultraviolet Irradiation of Cells
复制标题
胸腺嘧啶二聚体和紫外线照射细胞对 DNA 合成的抑制
作者：
R. Setlow;P. A. Swenson;W. Carrier
在细菌中的DNA合成的抑制和胸腺嘧啶二聚体的形成，通过紫外线照射的细胞的测量表明，一个胸腺嘧啶二聚体每350-IA链的DNA作为一个块进一步合成。在大肠杆菌的敏感菌株中，阻断是永久性的。在抗性菌株中，阻断只是暂时的，但合成的恢复不是分裂二聚体的结果。
Measurements of the inhibition of DNA synthesis in bacteria and the formation of thymine dimers by ultraviolet irradiation of the cells indicate that one thymine dimer per 350-IA strand of DNA acts as a block to further synthesis. In a sensitive strain of Escherichia coli the blocks are permanent. In a resistant strain the blocks are only temporary but recovery of synthesis is not the result of splitting dimers.