Monitoring response to convection-enhanced taxol delivery in brain tumor patients using diffusion-weighted magnetic resonance imaging.
Monitoring response to convection-enhanced taxol delivery in brain tumor patients using diffusion-weighted magnetic resonance imaging.
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发表时间：
2001-07
期刊：
影响因子：
11.2
通讯作者：
Y. Mardor;Yiftach Roth;Z. Lidar;Tali Jonas;Raphael Pfeffer;Stephan E. Maier;M. Faibel;D. Nass;Moshe Hadani;Arie Orenstein;Jack S. Cohen;Zvi Ram
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作者：
Y. Mardor;Yiftach Roth;Z. Lidar;Tali Jonas;Raphael Pfeffer;Stephan E. Maier;M. Faibel;D. Nass;Moshe Hadani;Arie Orenstein;Jack S. Cohen;Zvi Ram
对流增强给药技术是一种将药物直接输送到脑肿瘤组织的新方法。我们使用弥散加权磁共振成像（DWMRI）监测肿瘤内CEDD的影响，在三个脑肿瘤患者与泰素治疗。治疗开始后不久，观察到图像和水扩散参数的明显变化。最初，出现对应于降低的漫射的亮区域，随后在亮区域内出现漫射增加的暗区域。患者出现暗区的时间各不相同，表明反应率不同。在这项工作中，我们已经证明了使用DWMRI作为一种非侵入性的工具，以实现独特的早期组织定征的可行性，无法通过其他传统的成像方法。
Convection-enhanced drug delivery (CEDD) is a novel approach to enhance the delivery of drugs directly into brain tumors. We have used diffusion-weighted MRI (DWMRI) to monitor the effects of intratumoral CEDD in three brain tumor patients treated with Taxol. Clear changes in the images and the water diffusion parameters were observed shortly after the initiation of treatment. Initially, a bright area corresponding to decreased diffusion appeared, followed by the appearance of a dark area of increased diffusion within the bright area. The time to appearance of the dark area varied among the patients, suggesting different response rates. In this work, we have demonstrated the feasibility of using DWMRI as a noninvasive tool to achieve unique early tissue characterization not attainable by other conventional imaging methods.