Effective 3D viscoelasticity of red blood cells measured by diffraction phase microscopy.
Effective 3D viscoelasticity of red blood cells measured by diffraction phase microscopy.
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DOI：
10.1364/boe.2.000485
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发表时间：
2011-02-03
影响因子：
3.4
通讯作者：
Popescu G
中科院分区：
文献类型：
--
作者：
Wang R;Ding H;Mir M;Tangella K;Popescu G
我们提出了通过高灵敏度定量相位成像获得的纳米级红细胞波动的光学测量。这些时空波动是根据细胞的体粘弹性响应进行建模的。将位移分布与主体的存储模量和损耗模量联系起来具有将所有几何和皮质效应合并到单个有效介质行为中的优点。正常细胞的结果表明，在测量覆盖的整个频率范围内，粘性模量远大于弹性模量，表明流体行为。
We present optical measurements of nanoscale red blood cell fluctuations obtained by highly sensitive quantitative phase imaging. These spatio-temporal fluctuations are modeled in terms of the bulk viscoelastic response of the cell. Relating the displacement distribution to the storage and loss moduli of the bulk has the advantage of incorporating all geometric and cortical effects into a single effective medium behavior. The results on normal cells indicate that the viscous modulus is much larger than the elastic one throughout the entire frequency range covered by the measurement, indicating fluid behavior.