Antenatal phenobarbital in preventing intraventricular hemorrhage in premature newborns.
Antenatal phenobarbital in preventing intraventricular hemorrhage in premature newborns.
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产前苯巴比妥预防早产儿脑室内出血。
DOI：
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
S. Mancuso
中科院分区：
文献类型：
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作者：
S. De Carolis;M. D. De Carolis;A. Caruso;G. C. Oliva;C. Romagnoli;S. Ferrazzani;U. Muzii;R. Luciano;S. Mancuso
在一项随机前瞻性研究中，我们调查了 39 名打算分娩妊娠 32 周以下婴儿的妇女，产前苯巴比妥对新生儿脑室内出血的影响。治疗组接受静脉负荷剂量 700 mg 苯巴比妥，随后每日维持剂量直至分娩。新生儿在前 96 小时内接受苯巴比妥治疗。对婴儿的头部进行了超声波检查。治疗组脑室内出血的发生率显着降低：21 人中有 2 人 (9.5%)，而 18 人中有 9 人 (50%；p 小于 0.006)。此外，接受治疗的婴儿中没有发生严重出血（3-4 级）：21 名婴儿中有 0 名，18 名婴儿中有 5 名（27.7%；p 小于 0.01）。
In a randomized prospective study, we investigated the effect of antenatal phenobarbital on neonatal intraventricular hemorrhage in 39 women destined to deliver babies of less than 32 weeks of gestation. The treatment group received an intravenous loading dose of 700 mg of phenobarbital, followed by a daily maintenance dose until delivery. The newborns were treated with phenobarbital for the first 96 h. Ultrasound examinations of the infants' heads were performed. Intraventricular hemorrhage was significantly less frequent in the treated group: 2 of 21 (9.5%) versus 9 of 18 (50%; p less than 0.006). Moreover no severe hemorrhage (grade 3-4) occurred in the treated babies: 0 of 21 versus 5 of 18 (27.7%; p less than 0.01).