Salvage Surgery for Initially Unresectable Locally Advanced Hepatocellular Carcinoma Downstaged by Hepatic Arterial Infusion Chemotherapy
Salvage Surgery for Initially Unresectable Locally Advanced Hepatocellular Carcinoma Downstaged by Hepatic Arterial Infusion Chemotherapy
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DOI：
10.21873/anticanres.14479
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发表时间：
2020-08-01
影响因子：
2
通讯作者：
Okuda, Koji
中科院分区：
文献类型：
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作者：
Goto, Yuichi;Hisaka, Toru;Okuda, Koji
背景/目的：最近的研究已经证明了肝细胞癌（HCC）降级后挽救手术的有效性。本研究旨在评估肝动脉灌注化疗（HAIC）成功降级后挽救手术的结局。患者和方法：纳入了诊断为不可切除的局部晚期HCC并在HAIC转换为可切除状态后切除的患者。将患者分为Vp 3/4、Vv 2/3和无大血管侵犯（MVI）的患者，分析总生存率（OS）和无病生存率（DFS）。结果：18例患者被删失。其中，6例患者有Vp 3/4，4例患者有Vv 2/3，8例患者无MVI。Vp 3/4和无MVI患者的5年OS率分别为83%和73%，而Vv 2/3患者的5年OS率为0%（p
Background/Aim: Recent studies have demonstrated the efficacy of salvage surgery following downstaging of hepatocellular carcinoma (HCC). The aim was to assess the outcomes of salvage surgery after successful downstaging using hepatic arterial infusion chemotherapy (HAIC). Patients and Methods: Patients whose diagnosis was unresectable locally advanced HCC and who were resected after conversion to a resectable status by HAIC were included. The overall survival (OS) rate, and disease-free survival (DFS) rate were analyzed by stratifying patients into those with Vp3/4, Vv2/3, and those without major vascular invasion (MVI). Results: Eighteen patients were censored. Among them, six patients had Vp3/4, four patients had Vv2/3, and eight patients had no MVI. The 5-year OS rates of patients with Vp3/4 and those without MVI were 83% and 73%, respectively, whereas those with Vv2/3 had 0% (p