A menu-driven facility for power and detectable-difference calculations in stepped-wedge cluster-randomized trials
A menu-driven facility for power and detectable-difference calculations in stepped-wedge cluster-randomized trials
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DOI：
10.1177/1536867x1401400208
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发表时间：
2014-01-01
期刊：
影响因子：
4.8
通讯作者：
Girling, Alan
中科院分区：
文献类型：
--
作者：
Hemming, Karla;Girling, Alan
本文介绍了Stata菜单驱动程序steppedwedge，它计算可检测的差异和功率的steppedwedge随机试验。该命令允许使用双侧检验比较连续、二进制和速率结果（具有正态近似值）。该命令允许指定每个步骤随机化的簇数、步骤数和平均簇（单元）大小，或用户指定设计模式的不完整设计（每个簇一行，每个时间点一列的矩阵，以及指示暴露和可观察数据的条目）。聚类异质性可以使用聚类内相关性或（结果的）变异系数来参数化。该命令通过示例进行说明。
This article introduces the Stata menu-driven program steppedwedge, which calculates detectable differences and power for stepped-wedge randomized trials. The command permits continuous, binary, and rate outcomes (with normal approximations) for comparisons using two-sided tests. The command allows specification of the number of clusters randomized at each step, the number of steps and the average cluster (cell) size, or an incomplete design in which the user specifies the design pattern (a matrix with one row per cluster, one column per time point, and entries indicating exposure and observable data). Cluster heterogeneity can be parameterized using either the intracluster correlation or the coefficient of variation (of the outcome). The command is illustrated via examples.