Influence of Perceived Stress on Incident Amnestic Mild Cognitive Impairment: Results From the Einstein Aging Study.
Influence of Perceived Stress on Incident Amnestic Mild Cognitive Impairment: Results From the Einstein Aging Study.
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DOI：
10.1097/wad.0000000000000125
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发表时间：
2016-04
影响因子：
2.1
通讯作者：
Lipton RB
中科院分区：
文献类型：
--
作者：
Katz MJ;Derby CA;Wang C;Sliwinski MJ;Ezzati A;Zimmerman ME;Zwerling JL;Lipton RB
压力是遗忘型轻度认知障碍（aMCI）的一个潜在的可补救的风险因素。我们的目标是确定是否感知压力预测事件aMCI和确定压力对aMCI的影响是独立的已知aMCI的危险因素，特别是人口统计学变量，抑郁症和载脂蛋白（APOE）基因型。爱因斯坦老龄化研究（EAS）是一项基于社区的老年人纵向研究。每年在EAS中对参与者（N=507; 71例发生aMCI事件;平均随访时间= 3.6年S.D.）进行感知压力量表（PSS）评估。≥ 2.0），年龄≥ 70岁，基线PSS给药时无aMCI和痴呆，并且至少有一次后续年度随访。使用考克斯风险模型来检查调整协变量的至aMCI发作的时间。高水平的感知压力与aMCI事件风险增加30%相关（PSS每增加5分：HR=1.30; 95%CI：1.08-1.58），与协变量无关。协变量调整后的结果的一致性和缺乏证据的反向因果关系的纵向分析表明，这些结果是强大的。了解知觉压力对认知功能的影响，可能有助于制定预防aMCI和AD发病的干预策略。
Stress is a potentially remediable risk factor for amnestic Mild Cognitive Impairment (aMCI). Our objective is to determine whether perceived stress predicts incident aMCI and to determine the influence of stress on aMCI is independent of known aMCI risk factors, particularly demographic variables, depression and apolipoprotein (APOE) genotype. The Einstein Aging Study (EAS) is a longitudinal community based study of older adults. The Perceived Stress Scale (PSS) was administered annually in the EAS to participants (N=507; 71 developed incident aMCI; mean follow-up time = 3.6 years S.D. = 2.0) who were aged ≥ 70 years, free of aMCI and dementia at baseline PSS administration and had at least one subsequent annual follow-up. Cox hazard models were used to examine time to aMCI onset adjusting for covariates. High levels of perceived stress are associated with a 30% greater risk of incident aMCI (per 5 point increase in PSS: HR=1.30; 95% CI: 1.08–1.58) independent of covariates. The consistency of results after covariate adjustment and the lack of evidence for reverse causation in longitudinal analyses suggest that these findings are robust. Understanding of the effect of perceived stress on cognition may lead to intervention strategies that prevention the onset of aMCI and AD.