Molecular epidemiology of HIV-1 subtype A in former Soviet Union countries
Molecular epidemiology of HIV-1 subtype A in former Soviet Union countries
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DOI：
10.1371/journal.pone.0191891
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发表时间：
2018-02-01
期刊：
影响因子：
3.7
通讯作者：
Ali, Syed
中科院分区：
文献类型：
--
作者：
Aibekova, Lazzat;Foley, Brian;Ali, Syed
虽然在世界其他地区艾滋病毒感染率在下降，但在前苏联(FSU)国家，艾滋病毒感染率继续上升。本研究是为了调查前苏联国家的艾滋病毒传播模式和模式。我们对来自13个FSU国家的2705个HIV-1 A亚型Poll序列进行了系统发育分析：亚美尼亚、阿塞拜疆、白俄罗斯、爱沙尼亚、格鲁吉亚、哈萨克斯坦、吉尔吉斯斯坦、拉脱维亚、立陶宛、摩尔多瓦、俄罗斯、乌克兰和乌兹别克斯坦。我们的分析表明，来自FSU国家的集群是混合的，这表明轮回在艾滋病毒传播中可能起到了作用。注射吸毒是最常见的传播方式，而PWID和异性传播的聚集性混合在一起，表明艾滋病毒感染在人群中架起了桥梁。为控制该区域日益扩大的艾滋病毒流行，应将减少危害战略的重点放在三种传播方式上，即跨界移徙、注射吸毒和异性恋。
While in other parts of the world it is on decline, incidence of HIV infection continues to rise in the former Soviet Union (FSU) countries. The present study was conducted to investigate the patterns and modes of HIV transmission in FSU countries. We performed phylogenetic analysis of publicly available 2705 HIV-1 subtype A pol sequences from thirteen FSU countries: Armenia, Azerbaijan, Belarus, Estonia, Georgia, Kazakhstan, Kyrgyzstan, Latvia, Lithuania, Moldova, Russia, Ukraine and Uzbekistan. Our analysis showed that the clusters from FSU countries were intermixed, indicating a possible role of transmigration in HIV transmission. Injection drug use was found to be the most frequent mode of transmission, while the clusters from PWID and heterosexual transmission were intermixed, indicating bridging of HIV infection across populations. To control the expanding HIV epidemic in this region, harm reduction strategies should be focused on three modes of transmission, namely, cross-border migration, injection drug use and heterosexual.