Performance on the dementia rating scale in Parkinson's disease with dementia and dementia with Lewy bodies: comparison with progressive supranuclear palsy and Alzheimer's disease
Performance on the dementia rating scale in Parkinson's disease with dementia and dementia with Lewy bodies: comparison with progressive supranuclear palsy and Alzheimer's disease
复制标题
DOI：
10.1136/jnnp.74.9.1215
复制
发表时间：
2003-09-01
影响因子：
11
通讯作者：
Larsen, JP
中科院分区：
文献类型：
--
作者：
Aarsland, D;Litvan, I;Larsen, JP
背景资料：路易体痴呆（DLB）与帕金森病痴呆（PDD）的关系尚不清楚。目的：比较DLB和PDD患者的认知特征，并与皮质下痴呆患者的认知特征进行比较（进行性核上性麻痹）和皮质性痴呆（阿尔茨海默氏病）。设计：认知特征的调查。设置：挪威罗加兰县的一般社区和美国的一所大学痴呆和运动障碍研究中心。患者：60例DLB患者、35例PDD患者、49例进行性核上性麻痹患者和29例阿尔茨海默病患者，通过标准化临床程序和标准（所有PDD和阿尔茨海默病病例以及76%的进行性核上性麻痹病例）或尸检（所有DLB病例和24%的进行性核上性麻痹病例）诊断。痴呆严重程度的匹配使用的痴呆评定量表的总得分调整年龄和教育.主要结果measurements：痴呆评定量表的子得分校正年龄.结果：在PDD和DLB组的痴呆评定量表的子得分之间没有显着差异被发现在严重的痴呆患者;在轻度至中度痴呆患者中，PDD的概念化分项评分高于DLB（p=0.03）。与阿尔茨海默病相比，PDD和DLB具有更高的记忆子评分（p
Background: The relation between dementia with Lewy bodies (DLB) and Parkinson's disease with dementia (PDD) is unknown.Objectives: To compare the cognitive profiles of patients with DLB and PDD, and compare those with the performance of patients with a subcortical dementia (progressive supranuclear palsy) and a cortical dementia (Alzheimer's disease).Design: Survey of cognitive features.Setting: General community in Rogaland county, Norway, and a university dementia and movement disorder research centre in the USA.Patients: 60 patients with DLB, 35 with PDD, 49 with progressive supranuclear palsy, and 29 with Alzheimer's disease, diagnosed by either standardised clinical procedures and criteria (all PDD and Alzheimer cases and 76% of cases of progressive supranuclear palsy), or necropsy (all DLB cases and 24% of cases of progressive supranuclear palsy). Level of dementia severity was matched using the total score on the dementia rating scale adjusted for age and education.Main outcome measures: Dementia rating scale subscores corrected for age.Results: No significant differences between the dementia rating scale subscores in the PDD and DLB groups were found in the severely demented patients; in patients with mild to moderate dementia the conceptualisation subscore was higher in PDD than in DLB (p=0.03). Compared with Alzheimer's disease, PDD and DLB had higher memory subscores (p