Erythropoietin: a multimodal neuroprotective agent.
Erythropoietin: a multimodal neuroprotective agent.
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DOI：
10.1186/2040-7378-1-4
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发表时间：
2009-10-21
期刊：
影响因子：
--
通讯作者：
Sirén AL
中科院分区：
文献类型：
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作者：
Byts N;Sirén AL
造血生长因子促红细胞生成素（EPO）的组织保护功能与其对红细胞生成的作用无关。EPO及其受体（EPOR）在脑发育期间在多个脑细胞中表达，并且在损伤后在成人脑中上调。外周施用的EPO穿过血脑屏障并在脑中激活神经元、神经胶质和脑血管内皮细胞中的抗凋亡、抗氧化和抗炎信号传导，并刺激血管生成和神经发生。这些机制是其在中风、脑出血、创伤性脑损伤、神经炎症和神经退行性疾病的实验模型中的有效组织保护作用的基础。支持EPO用于脑部疾病的临床前数据已经转化为第一个临床试验研究，使用EPO作为神经保护剂获得了令人鼓舞的结果。
The tissue protective functions of the hematopoietic growth factor erythropoietin (EPO) are independent of its action on erythropoiesis. EPO and its receptors (EPOR) are expressed in multiple brain cells during brain development and upregulated in the adult brain after injury. Peripherally administered EPO crosses the blood-brain barrier and activates in the brain anti-apoptotic, anti-oxidant and anti-inflammatory signaling in neurons, glial and cerebrovascular endothelial cells and stimulates angiogenesis and neurogenesis. These mechanisms underlie its potent tissue protective effects in experimental models of stroke, cerebral hemorrhage, traumatic brain injury, neuroinflammatory and neurodegenerative disease. The preclinical data in support of the use of EPO in brain disease have already been translated to first clinical pilot studies with encouraging results with the use of EPO as a neuroprotective agent.