Actigraphic registration of motor activity reveals a more structured behavioural pattern in schizophrenia than in major depression.
Actigraphic registration of motor activity reveals a more structured behavioural pattern in schizophrenia than in major depression.
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DOI：
10.1186/1756-0500-3-149
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发表时间：
2010-05-27
影响因子：
1.8
通讯作者：
Fasmer, Ole B
中科院分区：
文献类型：
--
作者：
Berle, Jan O;Hauge, Erik R;Fasmer, Ole B
背景：运动活动模式障碍在精神分裂症和抑郁症中均可见。然而，这一活动很少被客观地研究。本研究的目的是用肌动记录仪研究这些患者运动活动模式的复杂性。FINDINGS：使用腕式活动记录仪记录精神分裂症和重度抑郁症患者为期2周的运动活动，并将他们与健康对照组进行比较。记录平均运动活动，并根据这些数据计算三个非参数变量：日间稳定性(IS)、日内变异性(IV)和相对幅度(RA)。精神分裂症患者和抑郁症患者的运动活动均显著低于对照组(P<0.001)和抑郁症患者(P<0.01)。精神分裂症患者的IS比对照组高，IV比对照组低，这反映了一种更有条理的行为模式。这种模式在接受氯氮平治疗的精神分裂症患者中尤为明显，而在抑郁症患者中未发现。结论：精神分裂症患者和抑郁症患者的运动活动都明显减少。然而，精神分裂症患者既不同于抑郁症患者，也不同于对照组，表现出运动活动模式，其特点是复杂性较低，行为更有条理。这些发现可能表明，与抑郁症相比，运动活动障碍反映了精神分裂症不同的病理生理机制。
BACKGROUND: Disturbances in motor activity pattern are seen in both schizophrenia and depression. However, this activity has rarely been studied objectively. The purpose of the present study has been to study the complexity of motor activity patterns in these patients by using actigraphy.FINDINGS: Motor activity was recorded using wrist-worn actigraphs for periods of 2 weeks in patients with schizophrenia and major depression and compare them to healthy controls. Average motor activity was recorded and three non-parametric variables, interdaily stability (IS), intradaily variability (IV), and relative amplitude (RA) were calculated on the basis of these data. The motor activity was significantly lower both in patients with schizophrenia (153 +/- 61, mean +/- SD, p < 0.001) and depression (187 +/- 84, p < 0.001), compared to controls (286 +/- 80). The schizophrenic patients had higher IS and lower IV than the controls reflecting a more structured behavioural pattern. This pattern was particularly obvious in schizophrenic patients treated with clozapine and was not found in depressed patients.CONCLUSIONS: Motor activity was significantly reduced in both schizophrenic and depressed patients. However, schizophrenic patients differed from both depressed patients and controls, demonstrating motor activity patterns marked by less complexity and more structured behaviour. These findings may indicate that disturbances in motor activity reflect different pathophysiological mechanisms in schizophrenia compared to major depression.