CD36 gene variants is associated with type 2 diabetes mellitus through the interaction of obesity in rural Chinese adults
CD36 gene variants is associated with type 2 diabetes mellitus through the interaction of obesity in rural Chinese adults
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CD36 基因变异通过中国农村成年人肥胖的相互作用与 2 型糖尿病相关
DOI：
10.1016/j.gene.2018.03.060
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发表时间：
2018
期刊：
影响因子：
3.5
通讯作者：
Hu Dongsheng
中科院分区：
文献类型：
--
作者：
Zhang Dongdong;Zhang Ruiyuan;Liu Yu;Sun Xizhuo;Yin Zhaoxia;Li Honghui;Zhao Yang;Wang Bingyuan;Ren Yongcheng;Cheng Cheng;Liu Xuejiao;Liu Dechen;Liu Feiyan;Chen Xu;Liu Leilei;Zhou Qionggui;Xiong Yihan;Xu Qihuan;Liu Jiali;Hong Shihao;You Ziyang;Hu Dongsheng
研究表明，聚类决定因子36 （CD36）蛋白在脂质代谢和胰岛素抵抗中起作用，CD36的表达可诱导肥胖。本研究评估了cd36变异与2型糖尿病（T2DM）风险的关系以及与肥胖的相互作用。方法在中国农村队列研究中进行病例对照研究。我们纳入546例T2DM与非T2DM对照，按性别、年龄（2 年内）、婚姻状况和居住村庄按1:1的比例进行匹配。采用snpscantm基因分型系统对4个基因座inCD36（rs1194197、rs2151916、rs3211956和rs7755）进行分型。结果在对潜在的混杂因素进行校正后，我们观察到cdd36多态性与T2DM风险之间没有统计学意义上的显著关联。与正常体重的野生型纯合子携带者相比，携带突变等位基因rs7755的超重/肥胖参与者患T2DM的风险增加了114% (OR = 2.14,95% CI: 1.33-3.46； p相互作用= 0.007)；携带突变等位基因rs7755的腹部肥胖参与者患T2DM的风险增加了133% （OR = 2.33,95% CI: 1.48-3.66； p相互作用= 0.002）。此外，rs2151916多态性与甘油三酯水平相关（P= 0.019），rs1194197变异与对照组收缩压相关（P= 0.023）。结论scd36基因型与T2DM进展无独立相关性。然而，我们的研究结果表明，cdd36变异与肥胖对2型糖尿病易感性之间存在正相互作用，这可能是通过心脏代谢紊乱引起的。
BackgroundEvidences show that cluster determinant 36 (CD36) protein plays a role in lipid metabolism and insulin resistance, and the expression of CD36 is inducible in obesity. The present study evaluated the association ofCD36variants and the interaction with obesity on type 2 diabetes mellitus (T2DM) risk.MethodsWe performed a case-control study nested in the Rural Chinese Cohort Study. We included 546 incident T2DM cases matched with non-T2DM controls in a 1:1 ratio by sex, age (within 2 years), marital status, and residence village. Four loci inCD36(rs1194197, rs2151916, rs3211956, and rs7755) were genotyped by SNPscanTMGenotyping system.ResultsAfter adjusting for potential confounding, we observed no statistically significant association between theCD36polymorphisms and T2DM risk. Compared to wild-type homozygous carriers with normal weight, overweight/obesity participants carrying the mutational allele rs7755 showed increased risk of T2DM, by 114% (OR = 2.14, 95% CI: 1.33–3.46;Pinteraction= 0.007); abdominal obesity participants carrying the mutational allele rs7755 showed increased risk of T2DM, by 133% (OR = 2.33, 95% CI: 1.48–3.66;Pinteraction= 0.002). Furthermore, rs2151916 polymorphism was associated with triglycerides level (P= 0.019), and the rs1194197 variant was related to systolic blood pressure (P= 0.023) within the group of controls.ConclusionsCD36genotypes were not associated with the progression to T2DM independently. However, our results suggested a positive interaction between theCD36variants and obesity on T2DM susceptibility, which might be through a cardiometabolic disorder.