Post-COVID-19 symptoms 6 months after acute infection among hospitalized and non-hospitalized patients.
Post-COVID-19 symptoms 6 months after acute infection among hospitalized and non-hospitalized patients.
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住院和非医院患者急性感染后6个月后，旋转后-19症状。
DOI：
10.1016/j.cmi.2021.05.033
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发表时间：
2021-10
期刊：
影响因子：
--
通讯作者：
Tascini C
中科院分区：
文献类型：
--
作者：
Peghin M;Palese A;Venturini M;De Martino M;Gerussi V;Graziano E;Bontempo G;Marrella F;Tommasini A;Fabris M;Curcio F;Isola M;Tascini C
评估2019冠状病毒病（COVID-19）后综合征发病6个月后的患病率和相关因素。双向前瞻性研究。采访调查了2020年3月至5月期间在乌迪内医院（意大利）就诊的所有连续成年COVID-19住院患者和门诊患者发病6个月后可能与COVID-19相关的症状。在症状出现6个月后，在访谈时，还评估了严重急性呼吸道综合征冠状病毒2型（SARS-CoV-2）的IgG抗体。共纳入599名个体（320名女性，53.4%;平均年龄53岁，SD 15.8），并在发病后187天（22 SD）进行了访谈。COVID-19后综合征的患病率为40.2%（241/599）。IgG抗体的存在与COVID-19后综合征的发生显著相关（OR 2.56，95% CI 1.48-4.38，p 0.001）和中位SARS-CoV-2 IgG滴度在COVID-19后综合征患者中显著高于无症状患者（42.1，IQR 17.1-78.4 vs. 29.1，IQR 12.1-54.2 kAU/L，p 0.004）。女性（OR 1.55，95%CI 1.05-2.27）、COVID-19发病时症状数量成比例增加（OR 1.81，95%CI 1.59-2.05）和ICU入院OR 3.10，95%CI 1.18-8.11）均为COVID-19后综合征的独立危险因素。同样的预测因子也出现在231例患者亚组中，在访谈时可获得血清学随访，同时抗SARS-CoV-2 IgG也成比例增加（OR 1.01，95% CI 1.00-1.02，p 0.04）。可以对COVID-10患者的特定亚组进行前瞻性随访，以确定典型症状和持续高抗SARS-CoV-2 IgG滴度，作为早期发现COVID-19后长期后遗症的手段。
To assess the prevalence of and factors associated with post-coronavirus disease 2019 (COVID-19) syndrome 6 months after the onset. A bidirectional prospective study. Interviews investigated symptoms potentially associated with COVID-19 6 months after the disease onset of all consecutive adult inpatients and outpatients with COVID-19 attending Udine Hospital (Italy) from March to May 2020. IgG antibodies against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) were also evaluated 6 months after the onset of symptoms, at the time of the interview. A total of 599 individuals were included (320 female, 53.4%; mean age 53 years, SD 15.8) and interviewed 187 days (22 SD) after onset. The prevalence of post-COVID-19 syndrome was 40.2% (241/599). The presence of IgG antibodies was significantly associated with the occurrence of post-COVID-19 syndrome (OR 2.56, 95% CI 1.48–4.38, p 0.001) and median SARS-CoV-2 IgG titres were significantly higher in patients with post-COVID-19 syndrome than in patients without symptoms (42.1, IQR 17.1–78.4 vs. 29.1, IQR 12.1–54.2 kAU/L, p 0.004). Female gender (OR 1.55, 95% CI 1.05–2.27), a proportional increase in the number of symptoms at the onset of COVID-19 (OR 1.81, 95% CI 1.59–2.05) and ICU admission OR 3.10, 95% CI 1.18–8.11) were all independent risk factors for post-COVID-19 syndrome. The same predictors also emerged in a subgroup of 231 patients with the serological follow-up available at the time of the interview alongside the proportional increase in anti-SARS-CoV-2 IgG (OR 1.01, 95% CI 1.00–1.02, p 0.04). Prospective follow-up could be offered to specific subgroups of COVID-10 patients, to identify typical symptoms and persistently high anti-SARS-CoV-2 IgG titres as a means of early detection of post-COVID-19 long-term sequelae.
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DOI：
10.1016/j.bbi.2010.04.012
发表时间：
2010-10
期刊：
Brain, behavior, and immunity
影响因子：
--
作者：
Broderick G;Fuite J;Kreitz A;Vernon SD;Klimas N;Fletcher MA
通讯作者：
Fletcher MA
影响因子：
3.7
作者：
Bardel, Annika;Wallander, Mari-Ann;Svardsudd, Kurt
通讯作者：
Svardsudd, Kurt
影响因子：
158.5
作者：
Ackermann, Maximilian;Verleden, Stijn E.;Jonigk, Danny
通讯作者：
Jonigk, Danny
影响因子：
33.9
作者：
Godfred-Cato, Shana;Bryant, Bobbi;Belay, Ermias
通讯作者：
Belay, Ermias
影响因子：
5
作者：
Plebani, Mario;Padoan, Andrea;Sciacovelli, Laura
通讯作者：
Sciacovelli, Laura