CYTOMEGALOVIRUS-SPECIFIC HUMORAL AND CELLULAR IMMUNE-RESPONSES IN HUMAN-PREGNANCY
CYTOMEGALOVIRUS-SPECIFIC HUMORAL AND CELLULAR IMMUNE-RESPONSES IN HUMAN-PREGNANCY
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DOI：
10.1093/infdis/143.3.391
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发表时间：
1981-01-01
影响因子：
6.4
通讯作者：
BALFOUR, HH
中科院分区：
文献类型：
--
作者：
GEHRZ, RC;CHRISTIANSON, WR;BALFOUR, HH
巨细胞病毒（CMV）特异性体液和细胞免疫进行了前瞻性评价期间和19例正常人妊娠后。血清阳性的妊娠受试者有淋巴细胞增殖反应纯化的CMV抗原，显着抑制妊娠晚期的结束，尽管持续水平的补体固定和免疫荧光抗体的CMV。这些降低的淋巴细胞增殖反应在分娩后一年恢复到妊娠早期检测到的水平。研究期间，无受试者排泄CMV。细胞免疫的一般参数，包括通过红细胞生成和有丝分裂原诱导的淋巴细胞增殖测定的胸腺衍生细胞计数，未受影响。妊娠期潜伏CMV的再激活可能与CMV特异性细胞免疫的短暂抑制有关。
Cytomegalovirus (CMV)-specific humoral and cellular immunity was evaluated prospectively during and after 19 normal human pregnancies. Seropositive pregnant subjects had lymphocyte proliferative responses to purified CMV antigen that were markedly depressed by the end of the third trimester of pregnancy despite persistent levels of complement-fixing and immunofluorescent antibodies to CMV. These reduced lymphocyte proliferative responses returned to levels detected early in pregnancy by one year after delivery. None of the subjects excreted CMV during the study period. General parameters of cellular immunity, including thymus derived-cell counts as determined by formation of erythrocyte rosettes and mitogen-induced lymphocyte proliferation, were unaffected. Reactivation of latent CMV during pregnancy might be related to transient depression of CMV-specific cellular immunity.