PROSTAGLANDIN AND THROMBOXANE BIOSYNTHESIS
PROSTAGLANDIN AND THROMBOXANE BIOSYNTHESIS
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DOI：
10.1016/0163-7258(91)90054-p
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发表时间：
1991-01-01
影响因子：
13.5
通讯作者：
DEWITT, DL
中科院分区：
文献类型：
--
作者：
SMITH, WL;MARNETT, LJ;DEWITT, DL
我们描述了花生四烯酸形成前列腺素 (PG) D2、PGE2、PGF2-α、9-α、11-β-PGF2、PGI2（前列环素）和血栓素 (Tx) A2 的酶学调节。我们讨论类前列腺素形成的三个主要步骤：（a）涉及磷脂酶 C、甘油二酯脂肪酶和单甘油酯脂肪酶的单磷脂酰肌醇以及涉及磷脂酶 A2 的磷脂酰胆碱的花生四烯酸动员； (b)由PGH合酶的环氧合酶和过氧化物酶活性催化形成前列腺素内过氧化物(PGG2和PGH2)； (c)从PGH2合成PGD2、PGE2、PGF2-α、9-α、11-β-PGF2、PGI2和TxA2。我们还提供了有关阿司匹林和其他非甾体抗炎药、地塞米松和其他抗炎类固醇、血小板衍生生长因子 (PDGF) 和白细胞介素 1 在前列腺素代谢中的作用的信息。
We describe the enzymological regulation of the formation of prostaglandin (PG) D2, PGE2, PGF2-alpha, 9-alpha, 11-beta-PGF2, PGI2 (prostacyclin), and thromboxane (Tx) A2 from arachidonic acid. We discuss the three major steps in prostanoid formation: (a) arachidonate mobilization from monophosphatidyl-inositol involving phospholipase C, diglyceride lipase, and monoglyceride lipase and from phosphatidyl-choline involving phospholipase A2; (b) formation of prostaglandin endoperoxides (PGG2 and PGH2) catalyzed by the cyclooxygenase and peroxidase activities of PGH synthase; and (c) synthesis of PGD2, PGE2, PGF2-alpha, 9-alpha, 11-beta-PGF2, PGI2, and TxA2 from PGH2. We also include information on the roles of aspirin and other nonsteroidal anti-inflammatory drugs, dexamethasone and other anti-inflammatory steroids, platelet-derived growth factor (PDGF), and interleukin-1 in prostaglandin metabolism.