Drug-related information generates placebo and nocebo responses that modify the drug response
Drug-related information generates placebo and nocebo responses that modify the drug response
复制标题
DOI：
10.1097/00006842-199903000-00018
复制
发表时间：
1999-03-01
影响因子：
3.3
通讯作者：
Olsen, H
中科院分区：
文献类型：
--
作者：
Flaten, MA;Simonsen, T;Olsen, H
目的：将肌肉松弛剂卡异丙醇和安慰剂的作用与卡异丙醇作用的激动或拮抗信息交叉。研究了信息是否单独引起生理和心理反应，以及信息是否改变了对药物的反应。方法：一半受试者服用含有525mg卡异丙醇胶囊，并告知药物的特定作用方式（松弛剂/C组、兴奋剂/C组和无信息组）。另一半受试者接受乳糖治疗（松弛组/L，兴奋组/L，无信息组/L）。因变量包括眨眼反射和皮肤电导反应、紧张和困倦的主观测量以及血清卡里异丙醇和甲丙酸盐浓度。在给药后15到130分钟之间进行录音。结果：与其他两组相比，兴奋剂/L组报告的紧张程度更高，卡异普罗多尔在兴奋剂/C组中增加的紧张程度更高。松弛剂/C组与其他服用卡异丙醇组相比，卡异丙醇的血清浓度更高。结论：报告的张力在刺激物信息提示的方向上被调节。卡异丙醇对张力的影响也受到刺激物信息的调节。在接受松弛剂信息的组中，卡异丙醇吸收增加可能是安慰剂反应的一种机制。
Objective: Administration of the muscle relaxant carisoprodol and placebo was crossed with information that was agonistic or antagonistic to the effect of carisoprodol. It was investigated whether information alone induced physiological and psychological responses, and whether information modified the response to the drug. Methods: Half of the subjects received capsules containing 525 mg carisoprodol together with information that the drug acted in a specific way (Groups Relaxant/C, Stimulant/C, and No Information/C). The other half of the subjects received lactose (Groups Relaxant/L, Stimulant/L, and No Information/L). Dependent variables were blink reflexes and skin conductance responses, subjective measures of tension and sleepiness, and serum carisoprodol and meprobamate concentrations. Recordings were made between 15 and 130 minutes after administration of the capsules. Results: The Stimulant/L, group reported more tension compared with the other two groups, and carisoprodol increased tension even more in the Stimulant/C group. The Relaxant/C group displayed higher levels of carisoprodol serum concentration compared with the other groups that received carisoprodol. Conclusions: Reported tension was modulated in the direction suggested by the stimulant information. The effect of carisoprodol on tension was also modulated by stimulant information. Increased carisoprodol absorption in the group that received relaxant information could be a mechanism in the placebo response.