Estimating breast tumor blood flow during neoadjuvant chemotherapy using interleaved high temporal and high spatial resolution MRI
Estimating breast tumor blood flow during neoadjuvant chemotherapy using interleaved high temporal and high spatial resolution MRI
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DOI：
10.1002/mrm.26684
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发表时间：
2018-01-01
影响因子：
3.3
通讯作者：
Buckley, David L.
中科院分区：
文献类型：
--
作者：
Georgiou, Leonidas;Sharma, Nisha;Buckley, David L.
目的评价一次标准注射造影剂后，同时获取高时间分辨率(HTR)动态增强(DCE)数据以定量乳腺肿瘤血流量(TBF)和高空间分辨率(HSR)DCE数据以供临床报告的交错采样策略。在一项前瞻性临床研究中，对18例接受新辅助化疗(NACT)的原发性乳腺癌患者进行了1.5T的交叉HTR和HSR DCE-MRI检查。肿瘤感兴趣区用两室示踪剂动力学模型分析。采用非参数Wilcoxon符号秩检验法对NACT前、后数据中的配对参数(n=10)进行比较。感兴趣区分析显示，NACT两个周期后总胆红素变化显著(0.81~0.43mLmin/mL；P=0.002)。HSR数据以正常方式报告，并能够评估肿瘤体积，NACT后肿瘤体积减少了53%(P=0.065)。结论使用所提出的策略可以可靠地测量TBF，而不会影响标准的临床方案。此外，在我们的可行性研究中，NACT后总胆红素显著降低，而毛细血管通透性表面积乘积则没有。Magn Reson Med 79：317-326,2018。(C)2017国际医学磁共振学会。
PurposeTo evaluate an interleaved MRI sampling strategy that acquires both high temporal resolution (HTR) dynamic contrast-enhanced (DCE) data for quantifying breast tumor blood flow (TBF) and high spatial resolution (HSR) DCE data for clinical reporting, following a single standard injection of contrast agent.MethodsA simulation study was used to evaluate the performance of the interleaved technique under different conditions. In a prospective clinical study, 18 patients with primary breast cancer, who were due to undergo neoadjuvant chemotherapy (NACT), were examined using interleaved HTR and HSR DCE-MRI at 1.5 Tesla. Tumor regions of interest were analyzed with a two-compartment tracer kinetic model. Paired parameters (n=10) from the data acquired before and post-cycle 2 of NACT were compared using the nonparametric Wilcoxon signed-rank test.ResultsSimulations demonstrated that TBF was reliably estimated using the proposed strategy. The region of interest analysis revealed significant changes in TBF (0.81-0.43mL/min/mL; P=0.002) following two cycles of NACT. The HSR data were reported in the normal way and enabled the assessment of tumor volume, which decreased by 53% following NACT (P=0.065).ConclusionsTBF can be measured reliably using the proposed strategy without compromising a standard clinical protocol. Furthermore, in our feasibility study, TBF decreased significantly following NACT, whereas capillary permeability surface-area product did not. Magn Reson Med 79:317-326, 2018. (c) 2017 International Society for Magnetic Resonance in Medicine.