Relationship of airway wall thickening to an imbalance between matrix metalloproteinase-9 and its inhibitor in asthma
Relationship of airway wall thickening to an imbalance between matrix metalloproteinase-9 and its inhibitor in asthma
复制标题
哮喘患者气道壁增厚与基质金属蛋白酶-9 及其抑制剂失衡的关系
DOI：
10.1136/thx.2004.028936
复制
发表时间：
2005-04-01
期刊：
影响因子：
10
通讯作者：
Mishima, M
中科院分区：
文献类型：
--
作者：
Matsumoto, H;Niimi, A;Mishima, M
背景资料：基质金属蛋白酶-9（MMP- 9）和基质金属蛋白酶组织抑制剂-1（TIMP- 1）之间的平衡可能在细胞外基质重塑（哮喘气道的特征）中起关键作用。TIMP- 1超过MMP- 9与慢性气流阻塞相关，但这种相关性的机制尚不清楚。最近的计算机断层扫描（CT）研究表明，气道壁增厚与慢性气流阻塞有关。采用经验证的CT技术测量经体表面积校正的气道壁面积，检测26例稳定期哮喘患者痰液中MMP- 9、TIMP- 1水平及其摩尔比，并评估其与肺功能和气道壁厚度的关系测量肺段支气管壁面积（WA/ BSA）、WA与外壁面积的比值（WA%）和经根部BSA校正的绝对壁厚（T/BSA）。结果：痰液MMP- 9水平与WA%呈负相关，TIMP- 1水平与WA/ BSA、T/ root BSA呈正相关。MMP- 9/ TIMP- 1摩尔比与WA%和T/！支气管扩张剂治疗后用力呼气中段流量和肺容积四分位最大呼气流量与BSA呈显著正相关。结论：过量的TIMP- 1可能在哮喘患者气道壁增厚，导致慢性气流阻塞中起作用。
Background: The balance between matrix metalloproteinase- 9 ( MMP- 9) and tissue inhibitor of metalloproteinase- 1 ( TIMP- 1) may be critical in extracellular matrix remodelling, a characteristic of asthmatic airways. An excess of TIMP- 1 over MMP- 9 has been associated with chronic airflow obstruction but the mechanisms underlying this association remain unknown. Recent computed tomographic ( CT) studies indicate that airway wall thickening is associated with chronic airflow obstruction.Methods: Sputum levels of MMP- 9, TIMP- 1, and their molar ratio were examined in 26 patients with stable asthma and their relationship with pulmonary function and airway wall thickness, assessed by a validated CT technique which measured wall area corrected by body surface area ( WA/ BSA), the ratio of WA to outer wall area ( WA%), and the absolute wall thickness corrected by root BSA of a segmental bronchus ( T/ ! BSA), was examined.Results: Sputum MMP- 9 levels were inversely correlated with WA% and TIMP- 1 levels were positively correlated with WA/ BSA and T/ root BSA. The MMP- 9/ TIMP- 1 molar ratio was inversely correlated with WA% and T/! BSA and positively correlated with post- bronchodilator values of mid- forced expiratory flow and maximum expiratory flow at the quartile of lung volume.Conclusion: Excess TIMP- 1 may have a pathogenetic role in airway wall thickening in asthmatic patients which may result in chronic airflow obstruction.