Effects of pH, ionic strength, and applied voltage on migration of dental monomers in an organic matrix
Effects of pH, ionic strength, and applied voltage on migration of dental monomers in an organic matrix
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DOI：
10.1016/j.dental.2011.08.399
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发表时间：
2011-11-01
期刊：
影响因子：
5
通讯作者：
Breschi, Lorenzo
中科院分区：
文献类型：
--
作者：
Colonna, Martino;Breschi, Marco;Breschi, Lorenzo
目标。已有研究表明，外加电场可以改善牙本质粘结系统(DBS)的粘结性能，从而改善牙本质粘结的粘结。然而，导致这一现象的机制尚未完全阐明。本研究的目的是阐明pH、基质离子强度和外加电压对常用DBS单体在模型基质(琼脂糖凝胶)中迁移的影响。一些常见的单体是双-GMA(2，2-双[4-(2-羟基-3-甲基丙烯酰氧基丙氧基)苯基]丙烷)；HEMA(甲基丙烯酸羟乙酯)；2-MP(双[2-(甲基丙烯酰氧基)乙基]磷酸酯)；TCDM[5-(2，5-二氧代tetrahydrofurfuryl)-3-methyl-3-cyclohexenyl-1，2-dicarboxylic酸)的甲基丙烯酸羟乙酯]酯；以及TEGDMA(三乙二醇二甲基丙烯酸酯)。将琼脂糖凝胶倒入一个水平的10孔电泳池中，用来模拟牙本质有机基质的胶原纤维。通过改变实验条件，考察了pH值、基质离子强度和电压对单体迁移的影响。在pH 3.1、6.3、8.5和12.3下，在低、中、高离子强度，以及在50和100V下进行的实验结果清楚地表明，这些参数中的每一个都会影响DBA单体向阳极和阴极的迁移。通过选择性地选择pH值、离子强度和外加电压，可以实现丙烯酸酯单体向阳极或阴极的迁移。还需要进一步的研究来评估DBS单体混合物在电场中对迁移的协同作用。(C)2011年牙科材料学会。爱思唯尔有限公司出版。保留所有权利。
Objectives. The application of an electric field has been shown to positively influence the bonding of dentin bonding systems (DBS) by improving adhesive impregnation into dentin. However, the mechanism responsible for this phenomenon has not been completely elucidated. The aim of this study was to clarify the effects of pH, matrix ionic strength, and applied voltage on the migration of commonly used DBS monomers in a model matrix (agarose gel).Methods. Some common monomers examined were bis-GMA (2,2-bis[4-(2-hydroxy-3-methacryloyloxy propoxy) phenyl] propane); HEMA (2-hydroxyethyl methacrylate); 2-MP (bis[2-(methacryloyloxy) ethyl] phosphate); TCDM [di(hydroxyethyl methacrylate) ester of 5-(2,5,-dioxo tetrahydrofurfuryl)-3-methyl-3-cyclohexenyl-1,2-dicarboxylic acid]; and TEGDMA (triethylene glycol dimethacrylate). Agarose gels poured into a horizontal 10-well electrophoretic cell were used to mimic the collagen fibrils of the dentin organic matrix. The role of pH, matrix ionic strength, and voltage on monomer migration was assayed by modifying the experimental conditions.Results. Results of experiments performed at pH 3.1, 6.3, 8.5, and 12.3; at low, medium, and high ionic strength; and at 50 and 100 V clearly showed that DBA monomer migration toward both the anode and the cathode can be affected by each of these parameters.Significance. Migration of acrylic monomers toward the anode or cathode can be achieved as desired by selective choice of pH, ionic strength, and applied voltage. Additional studies are needed to evaluate the synergistic effects of DBS monomer blends on migration in an electric field. (C) 2011 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.