Community level exposure to chemicals and oxidative stress in adult population
Community level exposure to chemicals and oxidative stress in adult population
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DOI：
10.1016/j.toxlet.2008.11.001
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发表时间：
2009-01-30
影响因子：
3.5
通讯作者：
Ha, Eun-Hee
中科院分区：
文献类型：
--
作者：
Hong, Yun-Chul;Park, Eun-Young;Ha, Eun-Hee
关于环境化学品暴露在氧化应激中的作用的信息很少。本研究旨在调查暴露于环境化学品，如多环芳烃，挥发性有机化合物，双酚A或邻苯二甲酸酯，是否会诱导城市成年人群的氧化应激。2005年4月至12月期间，共对960名居住在城市地区的成年人进行了评估。为了评估环境化学品暴露，我们测量了1-羟基芘、2-萘酚、马尿酸、甲基马尿酸、邻苯二甲酸单（2-乙基-5-羟己基）酯、邻苯二甲酸单（2-乙基-5-氧代己基）酯、邻苯二甲酸单丁酯和双酚A的尿液水平。尿丙二醛和8-羟基脱氧鸟苷也被用来评估氧化应激。经单因素回归分析，尿中化学暴露标志物浓度与氧化应激水平呈显著的剂量反应关系（P < 0.05）。在控制了年龄、性别、体重、吸烟和运动后，这些暴露生物标志物（双酚A除外）的回归系数在多元回归模型中保持显著性（P < 0.05）。氧化应激生物标志物显著影响胰岛素抵抗的指标，特别是葡萄糖水平。这项研究表明，环境化学品暴露与城市成年人群的氧化应激有关，并表明暴露于某些环境化学品可能有助于胰岛素抵抗。(C)2008爱思唯尔爱尔兰有限公司保留所有权利。
Little information is available on the role of environmental chemical exposure in oxidative stress. This study was designed to investigate whether exposure to environmental chemicals, such as polycylic aromatic hydrocarbons, volatile organic compounds, bisphenol A or phthalates, induces oxidative stress in urban adult Populations. A total of 960 adults dwelling in urban areas were evaluated between April and December 2005. To assess environmental chemical exposure, we measured urinary levels of 1-hydroxypyrene, 2-naphthol, hippuric acid, methyl hippuric acid, mono-(2-ethyl-5-hydroxyhexyl) phthalate, mono-(2-ethyl-5-oxohexyl) phthalate, and mono-butyl phthalate and bisphenol A. Urinary malondialdehyde and 8-hydroxydeoxyguanosine were also measured to evaluate oxidative stress. Significant dose-responsive relationship was found between Urinary concentrations of the chemical exposure biomarkers and oxidative stress levels in simple regression analyses (P < 0.05). Regression coefficients of these exposure biomarkers except bisphenol A remained significantly in the multiple regression models, after controlling for age, sex, weight, smoking, and exercise for at feast one of the two oxidative stress biomarkers (P < 0.05). The oxidative stress biomarkers significantly affected the indicators of insulin resistance, particularly glucose level. This study indicates that environmental chemical exposure is associated with oxidative stress in urban adult populations and suggests that exposure to certain environmental chemicals might contribute to insulin resistance. (C) 2008 Elsevier Ireland Ltd. All rights reserved.