Fructose-Rich Beverage Intake and Central Adiposity, Uric Acid, and Pediatric Insulin Resistance
Fructose-Rich Beverage Intake and Central Adiposity, Uric Acid, and Pediatric Insulin Resistance
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DOI：
10.1016/j.jpeds.2015.12.061
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发表时间：
2016-04-01
影响因子：
5.1
通讯作者：
Lee, Chien-Hung
中科院分区：
文献类型：
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作者：
Lin, Wei-Ting;Chan, Te-Fu;Lee, Chien-Hung
目的 确定含糖饮料 (SSB) 摄入量与胰岛素抵抗 (IR) 生物标志物之间的关联，并调查其与青少年肥胖和血清尿酸是否/如何相关。 研究设计 在一项监测台湾青少年代谢综合征多级风险状况的研究中，对青少年（n = 1454，年龄 12-16 岁）进行了评估。收集了有关人口统计、饮食、身体、人体测量和临床变量的详细信息。原始的 IR 稳态模型评估 (HOMA1-IR)、更新的 IR 非线性稳态模型评估 (HOMA2-IR) 模型以及多种 IR 标记物均被测量。 结果 摄入较多 SSB 的青少年更有可能出现空腹血清胰岛素、HOMA1-IR 和 HOMA2-IR 升高的情况（P 为趋势，每天摄入 350 mL 的高果糖玉米糖浆重质 SSB 的水平经多元调整后的 HOMA1-IR 和 HOMA2-IR 分别升高 0.52 和 0.30，分别解释了富含高果糖玉米糖浆的 SSB 中 25.4% 和 23.6% 以及 23.2% 和 20.6% 的 HOMA1-IR 和 HOMA2-IR 升高。肥胖青少年的摄入量得到加强（P 表示相互作用，
Objective To determine the association between sugar-sweetened beverage (SSB) consumption with biomarkers of insulin resistance (IR) and investigate whether/how this relates to obesity and serum uric acid in adolescents.Study design Adolescents (n = 1454, aged 12-16 years) were assessed in a study conducted to monitor Multilevel Risk Profiles for Adolescent Metabolic Syndrome in Taiwan. Detailed information about demographics, diet, physical, anthropometric, and clinical variables was collected. An original homeostatic model assessment of IR (HOMA1-IR), updated nonlinear homeostatic model assessment of IR (HOMA2-IR) model, and several IR markers were measured.Results Adolescents who consumed a greater amount of SSBs were more likely to have elevated fasting serum insulin, HOMA1-IR, and HOMA2-IR (P for trends, 350 mL/d intake of heavy high-fructose corn syrup-containing SSBs had a 0.52 and 0.30 higher multivariate-adjusted HOMA1-IR and HOMA2-IR, respectively. Waist circumference and serum uric acid were correspondingly found to explain 25.4% and 23.6%, as well as 23.2% and 20.6%, of the increases in the 2 IR markers. Both the elevations of HOMA1-IR and HOMA2-IR for high-fructose corn syrup-rich SSB intake were strengthened among obese adolescents (P for interaction,