Biomaterial based modulation of macrophage polarization: a review and suggested design principles
Biomaterial based modulation of macrophage polarization: a review and suggested design principles
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DOI：
10.1016/j.mattod.2015.01.019
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发表时间：
2015-07-01
期刊：
影响因子：
24.2
通讯作者：
O'Brien, Fergal J.
中科院分区：
文献类型：
--
作者：
Sridharan, Rukmani;Cameron, Andrew R.;O'Brien, Fergal J.
巨噬细胞长期以来以其吞噬能力和免疫防御而闻名;然而，近年来，由于它们能够转化为促炎和抗炎表型，它们在愈合中的作用越来越受到认可。历史上，生物材料被设计为惰性的，以尽量减少宿主反应。最近，组织工程和再生医学的出现导致了通过定制的机械，化学和时间特性与宿主相互作用的生物材料的设计。由于生物材料功能的进步和对巨噬细胞对植入材料的反应的更好理解，现在有可能确定决定宿主反应并有助于成功组织整合的生物材料设计特征。在此，我们开始简要回顾巨噬细胞的起源和巨噬细胞极化的关键细胞因子/趋化因子标志物，然后描述哪些反应有利于替代和再生生物材料。综述的主体集中于巨噬细胞极化，以响应由生物材料直接提供的固有线索以及由生物材料植入相关事件引起的后续线索。最后，提出了替代和再生生物材料的潜在设计原则。深入了解生物材料的线索，选择性地吞噬巨噬细胞可能证明有益的设计新一代的免疫知情的生物材料，可以积极地与免疫系统相互作用，以决定一个有利的巨噬细胞的反应后植入。
Macrophages have long been known for their phagocytic capabilities and immune defence; however, their role in healing is being increasingly recognized in recent years due to their ability to polarize into pro-inflammatory and anti-inflammatory phenotypes. Historically, biomaterials were designed to be inert to minimize the host response. More recently, the emergence of tissue engineering and regenerative medicine has led to the design of biomaterials that interact with the host through tailored mechanical, chemical and temporal characteristics. Due to such advances in biomaterial functionality and an improved understanding of macrophage responses to implanted materials, it is now possible to identify biomaterial design characteristics that dictate the host response and contribute to successful tissue integration. Herein, we begin by briefly reviewing macrophage cell origin and the key cytokine/chemokine markers of macrophage polarization and then describe which responses are favorable for both replacement and regenerative biomaterials. The body of the review focuses on macrophage polarization in response to inherent cues directly provided by biomaterials and the consequent cues that result from events related to biomaterial implantation. To conclude, a section on potential design principles for both replacement and regenerative biomaterials is presented. An in depth understanding of biomaterial cues to selectively polarize macrophages may prove beneficial in the design of a new generation of immuno-informed' biomaterials that can positively interact with the immune system to dictate a favorable macrophage response following implantation.