Concise synthesis of the chemopreventitive agent (±)-deguelin via a key 6-endo hydroarylation
Concise synthesis of the chemopreventitive agent (±)-deguelin via a key 6-endo hydroarylation
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DOI：
10.1021/ol035419j
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发表时间：
2003-10-30
期刊：
影响因子：
5.2
通讯作者：
Sames, D
中科院分区：
文献类型：
--
作者：
Pastine, SJ;Sames, D
[图]通过六个步骤的最长线性序列实现了 (+/-)-deguelin 的简明全合成，产率 68%。关键步骤是铂催化的炔酮中间体的 6-内加氢芳基化。
[GRAPHIC]A concise total synthesis of (+/-)-deguelin was achieved with a longest linear sequence of six steps in 68% yield. A key step was the platinum-catalyzed 6-endo hydroarylation of an alkynone intermediate.