Immunization with a carbohydrate mimicking peptide augments tumor-specific cellular responses.
Immunization with a carbohydrate mimicking peptide augments tumor-specific cellular responses.
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用碳水化合物模拟肽进行免疫可增强肿瘤特异性细胞反应。
DOI：
10.1093/intimm/13.11.1361
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发表时间：
2001
影响因子：
4.4
通讯作者：
Kieber-Emmons,T
中科院分区：
文献类型：
--
作者：
Monzavi-Karbassi,B;Cunto-Amesty,G;Luo,P;Shamloo,S;Blaszcyk-Thurin,M;Kieber-Emmons,T
The metastatic potential of some tumor cells is associated with the expression of the neolactoseries antigens sialyl-Lewis x (sLex) and sialyl-Lewis a (sLea) as they are ligands for selectins. We have recently shown that peptide mimetics of these antigens can potentiate IgG2a antibodies, which are associated with a Th1-type cellular response. As L-selectin is preferentially expressed on CD4+Th1 and CD8+T cell populations, specific induction of these phenotypes could augment a response to L-selectin ligand-expressing tumor cells. Here we demonstrate that immunization with a multiple antigen peptide (MAP) mimetic of sugar constituents of neolactoseries antigens induces a MHC-dependent peptide-specific cellular response that triggers IFN-γ production upon peptide stimulation, correlating with IgG2a induction. Surprisingly, T lymphocytes from peptide-immunized animals were activatedin vitroby sLex, also triggering IFN-γ production in a MHC-dependent manner. Stimulation by peptide or carbohydrate resulted in loss of L-selectin on CD4+T cells confirming a Th1 phenotype. We also observed an enhancement in cytotoxic T lymphocyte (CTL) activityin vitroagainst sLex-expressing Meth A cells using effector cells from Meth A-primed/peptide-boosted animals. CTL activity was inhibited by both anti-MHC class I and anti-L-selectin antibodies. These results further support a role forL-selectin in tumor rejection along with the engagement by the TCR for most likely processedtumor-associated glycopeptides, focusing on peptide mimetics as a means to induce carbohydrate reactive cellular responses.
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DOI：
10.1001/archsurg.1990.01410140084013
发表时间：
1990
期刊：
Archives of surgery (Chicago, Ill. : 1960)
影响因子：
--
作者：
Hoff,SD;Irimura,T;Matsushita,Y;Ota,DM;Cleary,KR;Hakomori,S
通讯作者：
Hakomori,S
活化 T 细胞调节 L-选择素的机制。
DOI：
--
发表时间：
1997
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Chao,CC;Jensen,R;Dailey,MO
通讯作者：
Dailey,MO
与碳水化合物抗原、唾液酸 SSEA-1 和抗体的免疫 T 细胞抗原位点相关的抗 Id 抗体特异性 T 细胞系的表征。
影响因子：
4.4
作者：
K. Tsuyuoka;K. Yago;K. Hirashima;S. Ando;N. Hanai;H. Saito;K. Yamasaki;K. Takahashi;Y. Fukuda;K. Nakao;R. Kannagi
通讯作者：
R. Kannagi
转化内皮细胞表达 L-选择素配体可增强 T 细胞介导的排斥反应。
DOI：
--
发表时间：
1999
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Biancone,L;Stamenkovic,I;Cantaluppi,V;Boccellino,M;DeMartino,A;Bussolino,F;Camussi,G
通讯作者：
Camussi,G
通过同时施用 IL-12 表达载体和 DNA 免疫原来体内改造细胞免疫反应。
影响因子：
4.4
作者：
Jong J. Kim;V. Ayyavoo;M. Bagarazzi;M. Chattergoon;K. Dang;Bin Wang;Jean D. Boyer;David B. Weiner
通讯作者：
David B. Weiner